是否家族性精神分裂症患者白介素6比较  

Comparison of plasma levels of interleukin-6 between familial and sporadic schizophrenia

作　　者：李恒芬[1] 姚丰菊[1] 孟焱[1] 郭新胜[2] 娄涛[1] 贾福军[1] 

机构地区：[1]新乡医学院第二附属医院精神科,河南新乡市453002 [2]新乡医学院第二附属医院检验科,河南新乡市453002

出　　处：《临床精神医学杂志》2002年第6期325-327,共3页Journal of Clinical Psychiatry

基　　金：河南省省级医学科技创新人才工程项目 (编号 :2 0 0 0 0 15 )

摘　　要：目的 :比较家族性精神分裂症 (FS)与散发性精神分裂症 (SS)患者血浆白介素 6 (IL 6 )水平差异 ,探讨其在发病机制中的作用。　方法 :采用酶联免疫吸附法 (ELISA)对FS患者 2 8例、SS患者 4 7例、FS患者的一级亲属 15例及 2 9名正常人的血浆IL 6水平进行检测 ;用阳性和阴性症状量表 (PANSS)评定患者的精神症状及严重程度。　结果 :FS患者组血浆IL 6水平明显高于SS患者组和正常对照组 ,而与FS患者的一级亲属组的IL 6水平差异无显著性 ;其IL 6水平与患者的阴性症状分呈正相关 ,与阳性症状分呈负相关 ,与疾病的严重程度无明显相关。SS患者组血浆IL 6水平低于FS患者的一级亲属组。　结论 :FS患者存在血浆IL 6介导的免疫功能异常 ,IL 6水平升高可能存在家族聚集性 ,且FS患者ILObjective:To compare the plasma levels of interleukin 6 between the patients with familial schizophrenia (FS) and sporadic schizophrenia(SS),and study its pathophysiological mechanisms in the disease. Method:Using enzyme linked immuno sorbent assay (ELISA),plasma levels of interleukin 6 were measured in 28 FS patients, 47 SS patients,15 first degree relatives, and 29 healthy controls. Mental symptoms and the severity of the disease were evaluated with positive and negative syndrome scale(PANSS). Results:Plasma interleukin 6 level was significantly higher in FS subgroup than in SS subgroup and healthy controls, and there were no significant differences in interleukin 6 between FS patients and the first degree relatives.Interleukin 6 levels in FS patients were positively related to the scores of negative symptoms, and negatively to the positive symptoms, whereas not related to the total PANSS scores. Interleukin 6 levels in SS patients were significantly lower compared with FS first degree relatives. Conclusion:There is immune dysfunction in familial schizophrenia, which may be mediated through interleukin 6.Familial aggregation presents in the phenomena of interleukin 6 level increasing. Plasma interleukin 6 levels is related to the characteristics of mental symptoms in FS patients.

关 键 词：家庭性精神分裂症 散发性精神分裂症 白介素6 FS 发病机制 

分 类 号：R749.3[医药卫生—神经病学与精神病学]