5-溴异苯并呋喃-1(3H)-酮合成方法改进  

Improved synthesis of 5-bromoisobenzofuran-1(3H)-one

作　　者：余红霞[1] 郭峰[2] 

机构地区：[1]武汉化工学院制药系,湖北武汉430073 [2]湖北工学院化工系,湖北武汉430068

出　　处：《中国药物化学杂志》2002年第6期352-353,共2页Chinese Journal of Medicinal Chemistry

摘　　要：以邻苯二甲酰亚胺为起始原料 ,经硝化、还原、溴代等步骤 ,合成 5 溴异苯并呋喃 1(3H) 酮 ,总收率为 4 0 % (以邻苯二甲酰亚胺计 ) ,纯度达 99 6 %。In this article,phthalimide was chosen as the start material.The 5 bromoisobenzofuran 1(3 H ) one was obtained via nitration,reduction and bromination,the overall yield was 40% and the purity of the product was 99 6%.

关 键 词：合成方法 5-溴异苯并呋喃-1-酮 硝化 还原 溴代 

分 类 号：TQ463[化学工程—制药化工]