急性重复前脑缺血再灌注对大脑皮层电图的影响  

Effects of Acute Repeated Forebrain Ischemia and Reperfusion on the Electrocorticogram in Rats

作　　者：代荣晓[1] 赵国举[1] 王星文[1] 任世兰[1] 

机构地区：[1]郧阳医学院药理教研室

出　　处：《郧阳医学院学报》1997年第4期191-193,共3页Journal of Yunyang Medical College

摘　　要：目的：探讨急性重复前脑缺血与缺血耐受的关系。方法：采用Ｐｕｌｓｉｎｅｌｉ四血管闭塞法略加改良制成大鼠前脑缺血再灌注模型观察脑缺血及再灌注期的ＥＣｏＧ及ＥＣＧ变化。结果：重复２．５ｍｉｎ短暂缺血，随次数的增多，ＥＣＧ复灌１０ｍｉｎ时的恢复渐降低，１，２，３次分别为（７８．８±１６．０）％，（５３．２±１８．１）％，（３２．８±２５．６）％，差异显著。多次缺血再灌注组与单次持续缺血再灌注组比较，ＥＣＯＧ的恢复在１０，２０，３０，４０ｍｉｎ时波幅较低。整个试验过程中，ＥＣＧ变化较小。结论：急性短暂缺血不能诱导缺血耐受，更可能造成累加性损害。Objective:To investgate the relationship of acute repeated forebrain ischemia and reperfusion with ischemic tolerance Methods:The 4-vessel occlusion(4-VO) method based on slightly improved Pulsinelli model was regarded as the model of the forebrain ischemia and reperfusion in rats in order to investigate the variation of ECOG and EEG during the ischemia and reperfusion.Results:With increase of times of repeated transient ischemia for 5 min,the recovery height percentage of 1～3 times gradually decrease(78.8±16.0)%,(53.2±18.1)%,(32.8±25.6)% and has significant difference(P<0.01 or 0.05).The recovery percertage at 10,20,30,40 minwas higher in single consistant ischemia for 30 min than many consistant ischemia following acute repeated ischemia.Conclusion:It is possible that this kind of acute repeated transient ischemia is not able to induce ischemic toleranc, but bring about accumulated damage.

关 键 词：脑缺血 再灌注损伤 皮层电图 

分 类 号：R743.31[医药卫生—神经病学与精神病学]