E-cadherin/catenins与肿瘤发生、侵袭及转移  

E-cadherin/catenins and the Occurrence, Attack,Transfer of Tumour

作　　者：杨剑锋[1] 廖粤军 徐增绶[3] 

机构地区：[1]湖南师范大学,医学院,湖南,长沙,410000 [2]衡南县人民医院 [3]华中科技大学,同济医学院

出　　处：《南华大学学报（医学版）》2002年第4期391-394,共4页Journal of Nanhua University(Medical Edition)

摘　　要：粘附分子E -cadherin通过catenins与细胞骨架相连介导细胞同质粘附作用。E -cadherin catenins复合物抑制肿瘤侵袭、转移的作用引起广泛重视。β -catenin除与E -cadherin结合介导细胞同质粘附反应 ,还参与Wnt信号传导通路与肿瘤发生有关。本文主要就E -cadherin catenins在肿瘤发生、侵袭及转移中的作用研究进展做一综述。E-cadherin mediated cell-cell homophilic adhesion ,which is linked to the cytoskeleton via catenins. Recent evidence indicates that changes in the expression and function of E-cadherin/catenins complex is important to the process of tumour invasion and metastasis. β-catenin not only regulates cell-cell adhesion as a protein interacting with cadherin, but also functions as a component of the Wnt signaling pathway which leads to tumor formation when aberrantly activated. This article will give an overview of the role of E-cadherin/catenins in tumour formation, invasion and metastasis.

关 键 词：上皮性钙粘素 连接素 肿瘤发生 侵袭 转移 

分 类 号：R73－37[医药卫生—肿瘤]