放射治疗诱发恶性肿瘤10例临床分析  

Radiation Induced Malignant Tumors(A Report of 10 cases)

作　　者：苏茂昆[1] 王若峥[1] 

机构地区：[1]新疆医科大学附属肿瘤医院,新疆乌鲁木齐830011

出　　处：《新疆医科大学学报》2002年第4期420-421,共2页Journal of Xinjiang Medical University

摘　　要：目的:探讨放射线诱发恶性肿瘤的有关因素。方法:回顾性分析 10例放射线治疗后诱发的恶性肿瘤。原发肿瘤为鼻咽癌 5例 ,扁桃体癌、扁桃体恶性淋巴瘤、鼻腔内翻乳头状瘤恶变、左眼眶下血管外皮瘤及垂体腺瘤各 1例。放射原为 6MVX线或 6 0 Coγ线 ,放射剂量 3 0～ 77Gy,常规分割。 结果:放射治疗后 2～ 2 6年 ,在照射野内或射野边缘诱发恶性肿瘤。 结论 :放射线可诱发恶性肿瘤 ,与照射部位、射线剂量。Objective: It attempted to analyze possible etiologic factors of radiation induced malignant tumors. Methods: 10 cases of radiation induced malignant tumors were reported. Their primary tumors were nasopharyngeal carcinoma 5, tonsillar malignant lymphoma 1, tonsillar carcinoma 1, malignant change of the inverted papilloma 1, pituitary adenoma 1, suborbital hemoagiopericgtoma 1. The initial radiotherapy was 60 Co or 6 MV X ray, conventionally fractionated at dose of 30~75 Gy. Results: After 2~26 years of the initial radiotherapy 10 patients developed tumors within the original radiation fields. The tumors were malignant peripheral nerve sheath tumors, parotid carcinoma, well differentiated squamous carcinoma of gingival, squamous carcinoma of external ear. Squamous carcinoma of the root of the tongue. 3 cases poorly differentiated squamous carcinoma of naopharyneal, maxillary sinus cancer and fibrosarcoma of the nasal cavity respectively. Conclusion: The etiologic factors of radiation induced cancer are related to total dose, age and the site of radiotherapy.

关 键 词：恶性肿瘤 临床分析 放射疗法 诊断 治疗 

分 类 号：R730.55[医药卫生—肿瘤]