大肠癌术后复发与血管内皮细胞生长因子及其受体表达的关系  

Relationship between Recurrence in Colorectal Carcinomas and Expression of Vascular Endothelial Growth Factor with Its Receptor KDR

作　　者：李俊[1] 曹桦[1] 吴宁[1] 孟红[1] 汪永寿[1] 陈玉祥[1] 程雄[1] 

机构地区：[1]四川德阳市人民医院,四川德阳618000

出　　处：《华西医学》2002年第4期486-488,共3页West China Medical Journal

摘　　要：目的 :研究血管内皮细胞生长因子 (VEGF)及其受体 (KDR)与大肠癌术后复发的关系。方法 :应用免疫组化SP法检测 94例大肠癌标本VEGF及KDR蛋白表达 ,分析VEGF和KDR与临床病理因素、微血管密度(MVD)及术后复发的关系。结果 :VEGF和KDR表达与大肠癌Duke分期、淋巴结转移密切相关 (P <0 0 1) ,而与组织学分型无关 (P >0 0 5 )。VEGF和KDR表达阳性组MVD显著高于阴性组 (P <0 0 1)。大肠癌术后复发与VEGF、KDR密切相关 ,VEGF组 (P <0 0 1) ,KDR组 (P <0 0 5 )。但各复发转移部位的关系并不密切 (P >0 0 5 )。结论 :VEGF和KDR与大肠癌血管生成相关 ,在大肠癌的发生、发展及术后复发中起重要作用 ,可反映大肠癌的进展情况 ,并可作为判断预后的指标。Objective:To investigate the relationship between recurrence of colorectal carcinomas and the expression of vascular endothelial growth factor(VEGF)with its receptor(KDR).Methods:SP immunohistochem istry was applied to examine the expression of VEGF and KDR in 94 cases of color ectal specimen.The relations were analysed between the expression of VEGF with KDR and clinicopathological factors,microvessels density(MVD)and colorectal carcinoma recurrence.Results:the expression of VEGF and KDR were highly correlated with Duke's stage and lymph nodes metastasis( P <0 01),while no significant correlation was found with histologic type( P >0 05).MVD was significantly higher in the VEGF and KDR positive group than the negative group( P <0 01).VEGF and KDR expression were closely correlated with tumor recurrence,VEGF group( P <0 01),and KDR group( P <0 05).The sites of recurrence and metastasis had no relationship with expressions( P >0 05).Conclusions:VEGF and KDR were played an important role in the angiogenesis origination,progress and recurrence of colorectal carcinoma,and could be taken as a prognostic marker.

关 键 词：大肠癌 术后复发 血管内皮细胞生长因子 受体 微血管密度 

分 类 号：R735.34[医药卫生—肿瘤]