血清微RNA-126微RNA-143对颅内动脉瘤术后病情复发的预测价值  

The predictive value of serum miRNA-126 and miRNA-143 for postoperative recurrence of intracranial aneurysms

作　　者：刘延红 Liu Yanhong(Department of Neurosurgery,the First Affiliated Hospital of Nanyang Medical College,Nanyang 473000,China)

机构地区：[1]南阳医学高等专科学校第一附属医院神经外科,南阳473000

出　　处：《实用医技杂志》2024年第12期891-895,I0002,共6页Journal of Practical Medical Techniques

摘　　要：目的分析血清微RNA(miR)-126、miR-143对未破裂型颅内动脉瘤(UIA)患者术后病情复发的预测价值。方法以南阳医学高等专科学校第一附属医院2022年6月至2023年6月期间收治的102例接受介入治疗的UIA患者作为本次研究对象,所有患者均接受血管内介入栓塞术治疗,术后均随访1年,依据术后病情是否复发,将其分别列为复发组(32例)、未复发组(70例),收集2组患者的一般资料、临床资料进行单因素分析、logistic多因素回归分析,归纳导致UIA患者术后病情复发的危险因素;通过绘制受试者工作特征(ROC)曲线并观察曲线下面积(AUC)验证血清miR-126、miR-143对UIA术后病情复发的预测价值。结果单因素分析结果显示,复发组中合并高血压占比、流入角、动脉瘤直径、动脉瘤颈宽度、术后即刻Raymod分级≥Ⅱ级占比、直接弹簧圈栓塞占比、血清miR-126均高于未复发组,血清miR-143低于未复发组(P均<0.05);logistic多因素回归分析结果显示,流入角、动脉瘤直径、术后即刻Raymod分级、单纯弹簧圈栓塞、miR-126、miR-143为UIA术后复发的危险因素。经ROC曲线验证,血清miR-126对UIA术后病情复发的预测灵敏度、特异度分别为82.26%、78.44%,血清miR-143对UIA术后病情复发的预测灵敏度、特异度分别为80.29%、77.95%(AUC>0.85)。结论流入角过大、动脉瘤直径过长、术后即刻Raymod分级为≥Ⅱ级、单纯弹簧圈栓塞以及血清miR-126高表达,血清miR-143低表达均为UIA患者术后病情复发的危险因素,动态监测血清miR-126、miR-143表达水平能实现对患者术后复发风险的早期预测。Objective To analyze the predictive value of serum microRNA-126(miR-126)and microRNA-143(miR-143)for postoperative disease recurrence in patients with unruptured intracranial aneurysm(UIA).Methods With 102 patients with UIA admitted to our hospital from June 2022 to June 2023.All patients received endovascular embolization treatment,all patients were followed up for six months one year after surgery,and were divided into a recurrence group(32 cases)and a non-recurrence group(70 cases)based on whether their condition recurred.General and clinical data of the two groups of patients were collected for univariate analysis and logistic multivariate regression analysis to summarize the risk factors for postoperative disease recurrence in UIA patients.the predictive value of serum miR-126 and miR-143 for postoperative disease recurrence in UIA was verified by plotting ROC and observing AUC.Results The results of univariate analysis showed that the proportion of hypertension,inflow angle,aneurysm diameter,aneurysm neck width,Raymod grade≥Ⅱafter surgery,simple coil embolization,and serum miR-126 in the recurrence group were higher than those in the non-recurrence group,the serum miR-143 was lower than that of the non-recurrent group(all P<0.05).Logistic multivariate regression analysis showed that inflow angle,aneurysm diameter,immediate Raymod grading after surgery,simple coil embolization,miR-126,and miR-143 were risk factors for postoperative recurrence of UIA.Through ROC curve validation,the sensitivity and specificity of serum miR-126 for predicting postoperative disease recurrence in UIA were 82.26%and 78.44%,respectively.The sensitivity and specificity of serum miR-143 for predicting postoperative disease recurrence in UIA were 80.29%and 77.95%,respectively(AUC>0.85).Conclusion Excessive inflow angle,long aneurysm diameter,Raymod grade≥Ⅱimmediately after surgery,simple coil embolization,and high serum miR-126 expression and low serum miR-143 expression are all risk factors for postoperative disease recurren

关 键 词：颅内动脉瘤 神经外科手术 复发 危险因素 微RNAS 

分 类 号：R73[医药卫生—肿瘤]