左甲状腺素钠联合碘131对老年高危分化型甲状腺癌术后患者的效果分析  

Effect of Levothyroxine Sodium Combined with Iodine131 on Hormone Recovery,Serum Thyroglobulin Level and Immune Function in Elderly Patients with High-Risk Differentiated Thyroid Cancer after Operation

作　　者：葛树杰 袁媛 周晓静 沈如月 GE Shujie;YUAN Yuan;ZHOU Xiaojing;SHEN Ruyue(The First Affiliated Hospital of Bengbu Medical University,Bengbu 233000,China;不详)

机构地区：[1]蚌埠医科大学第一附属医院,安徽蚌埠233000

出　　处：《中外医学研究》2024年第36期35-38,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨左甲状腺素钠联合碘131对老年高危分化型甲状腺癌(differentiated thyroid carcinoma,DTC)术后患者激素恢复、血清甲状腺球蛋白水平、免疫功能的影响。方法:选取2022年11月—2023年10月在蚌埠医科大第一附属医院接受治疗的120例老年DTC术后患者作为研究对象,随机分为131组和试验组,每组各60例。131组采用碘131治疗,试验组采用碘131联合左甲状腺素钠治疗,治疗周期为12周。观察两组治疗前后激素水平、血清甲状腺球蛋白水平、免疫功能变化情况。结果:治疗前两组各项生化指标比较,差异无统计学意义(P>0.05);治疗12周后,试验组促甲状腺激素(TSH)水平低于131组,游离四碘甲状腺原氨酸(FT4)、游离三碘甲状腺原氨酸(FT3)水平高于131组,差异有统计学意义(P<0.05)。试验组甲状腺球蛋白(Tg)、抗甲状腺球蛋白抗体(TgAb)水平低于131组,差异有统计学意义(P<0.05)。试验组CD3^(+)、CD4^(+)高于131组,CD8^(+)低于131组,差异有统计学意义(P<0.05)。结论:碘131联合左甲状腺素钠治疗能够维持老年DTC患者的甲状腺激素和血清甲状腺球蛋白的水平,提高患者的免疫功能。Objective:To explore the influence of levothyroxine sodium combined with iodine 131 on hormone recovery,serum thyroglobulin level and immune function in elderly patients with high-risk differentiated thyroid cancer (DTC) after operation.Method:A total of 120 elderly postoperative DTC patients admitted to the First Affiliated Hospital of Bengbu Medical University from November 2022 to October 2023 were selected as the study objects and randomly divided into 131 groups and experimental groups,with 60 cases in each group.131 group was treated with iodine131,while experimental group was treated with iodine131 combined with levothyroxine sodium.The treatment cycle was 12 weeks.The changes of hormone level,serum thyroglobulin level and immune function before and after treatment were observed.Result:There was no significant difference in biochemical indexes between the two groups before treatment (P>0.05).After 12 weeks of treatment,the TSH level in the experimental group was lower than that in 131 group,and the difference is statistically significant (P<0.05).And the free Thyroxine (FT4) and free Triiodothyronine (FT3) levels in the experimental group were significantly higher than that in 131 group,the difference is statistically significant (P<0.05).The levels of thyrogloblin (Tg) and thyroglobulin (TgAb) in experimental group were significantly lower than those in 131 group,and the difference is statistically significant (P<0.05).CD3^(+) and CD4^(+) in the experimental group were significantly higher than those in 131 group,and the difference is statistically significant (P<0.05).While CD8^(+) in the experimental group was significantly lower than that in 131 group,and the difference is statistically significant (P<0.05).Conclusion:Iodine131 combined with levothyroxine sodium can maintain the levels of thyroid hormone and serum thyroglobulin in elderly DTC patients and improve their immune function.

关 键 词：碘131 左甲状腺素钠 高危分化型甲状腺 甲状腺激素 血清甲状腺球蛋白水平 免疫功能 

分 类 号：R73[医药卫生—肿瘤]