CO_(2)激光对阴道上皮内瘤变患者阴道微生态、HPV转阴率和复发率的影响  

The Effect of CO_(2) Laser on Vaginal Microecology,HPV Conversion Rate and Recurrence Rate in Patients with Vaginal Intraepithelial Neoplasia

作　　者：范欣 王翠兰 叶黔 FAN Xin;WANG Cuilan;YE Qian(Nanping First Hospital,Nanping 353000,China;不详)

机构地区：[1]南平市第一医院,福建南平353000

出　　处：《中外医学研究》2024年第36期122-125,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探究CO_(2)激光对阴道上皮内瘤变(VAIN)患者阴道微生态、人乳头瘤病毒(HPV)转阴率和复发率的影响。方法:选取2022年1月—2023年1月南平市第一医院收治的102例VAIN患者作为研究对象,按随机数表法分为对照组(常规治疗,n=51)和研究组(在对照组基础上采取CO_(2)激光治疗,n=51)。比较两组疗效、阴道微生物、HPV转阴率以及复发率,并总结CO_(2)激光治疗VAIN的临床经验。结果:治疗后,研究组治愈率高于对照组,复发率低于对照组,差异有统计学意义(P<0.05);治疗后,研究组Nugent评分、阴道分泌物pH值均低于对照组,差异有统计学意义(P<0.05);研究组阴道微生态正常或恢复率高于对照组,差异有统计学意义(P<0.05);治疗后,研究组宫颈灌洗液中干扰素(INF-γ)、白介素12(IL-12)高于对照组,白介素4(IL-4)、肿瘤坏死因子-α(TNF-α)低于对照组,差异有统计学意义(P<0.05);治疗后,研究组HPV转阴率、总有效率均高于对照组,差异有统计学意义(P<0.05)。结论:CO_(2)激光治疗VAIN患者可提高治愈率、HPV转阴率,平衡阴道微生态,降低阴道炎症以及复发率。Objective:To investigate the effect of CO_(2) laser on vaginal microecology,human papillomavirus (HPV) conversion rate and recurrence rate in patients with vaginal intraepithelial neoplasia (VAIN).Method:102 VAIN patients,admitted to Nanping First Hospital from January 2022 to January 2023,were divided into the control group (conventional treatment,n=51) and the study group according to the random number table method (CO_(2) laser treatment on the basis of the control group,n=51).The efficacy,vaginal microorganism,HPV conversion rate and recurrence rate were compared between the two groups,and the clinical experience of CO_(2) laser treatment for VAIN was summarized.Result:After treatment,the cure rate in the study group was was higher than that in the control group,the recurrence rate in the study group was lower than that in the control group,with statistical significant (P<0.05).After treatment,the Nugent score and the pH value of vaginal secretions in the study group were lower than that of the control group,with statistical significant (P<0.05).The vaginal micronormality or recovery rate in the study group was higher than that of the control group,with statistical significant (P<0.05).After treatment,interferon (INF-γ) and interleukin 12 (IL-12) were higher than those in the study group,and interleukin 4 (IL-4) and tumor necrosis factor-α (TNF-α) were lower than those in the control group,and the differences were statistically significant (P<0.05).After treatment,the HPV conversion rate and total response rate of the study group were higher than those of the control group,and the differences were statistically significant (P<0.05).Conclusion:CO_(2) laser treatment of VAIN patients can improve the cure rate,HPV turning rate,balance vaginal microecology,and reduce vaginal inflammation and recurrence rate.

关 键 词：CO_(2)激光 阴道上皮内瘤变 阴道微生态 人乳头瘤病毒 疗效 

分 类 号：R73[医药卫生—肿瘤]