幽门螺杆菌胃炎合并小肠细菌过度生长的临床诊治进展  

Progress in the clinical diagnosis and treatment of Helicobacter pylorigastritis complicated with small intestinal bacterial overgrowth

作　　者：杨吉香 马颖才(综述)[1] 周思思(审校)[1] YANG Jixiang;MA Yingcai;ZHOU Sisi(Department of Gastroenterology,Qinghai Provincial People′s Hospital,Xining,Qinghai 810007,China)

机构地区：[1]青海省人民医院消化内科,青海西宁810007

出　　处：《检验医学与临床》2025年第1期137-140,144,共5页Laboratory Medicine and Clinic

基　　金：青海省卫生健康委员会重点项目[青卫医(2020)198号];青海省科技厅创新平台建设项目(2019-SF-L5)。

摘　　要：胃肠道微生物群与宿主的健康密不可分,近年研究发现幽门螺杆菌(Hp)胃炎和小肠细菌过度生长(SIBO)均存在肠道微生态失衡,且二者的临床症状有一定的重叠,因此有观点认为Hp胃炎与SIBO存在一定的关系,目前关于这方面的临床诊治研究较少,该文阐述了Hp胃炎合并SIBO的发生情况及病理生理机制,重点讨论了小肠内容物细菌培养法、呼气试验及新型检测技术诊断Hp胃炎合并SIBO的优缺点,以及Hp根除治疗和益生菌疗法对SIBO的疗效。对于Hp胃炎合并SIBO的临床诊治仍然存在一定的困难,未来需要更多高质量的临床研究来指导用药方案。Gastrointestinal microbiota is inseparable from the health of the host,in recent years,studies have found that both Helicobacter pylori(Hp)gastritis and intestinal bacterial overgrowth(SIBO),and their clinical symptoms overlap to a certain extent.Therefore,it is believed that there is a certain relationship between Hp gastritis and SIBO,which is rarely studied in clinical diagnosis and treatment at present.This paper describes the occurrence and pathophysiological mechanism of Hp gastritis complicated with SIBO.The advantages and disadvantages of bacterial culture,breath test and novel detection techniques in diagnosing Hp gastritis with SIBO are discussed,and the efficacy of Hp eradication therapy and probiotic therapy in SIBO are also discussed.The clinical diagnosis and treatment of Hp gastritis with SIBO remain difficult,and more high-quality clinical studies are needed to guide medication regimens in the future.

关 键 词：幽门螺杆菌 慢性胃炎 小肠细菌过度生长 呼气试验 治疗 

分 类 号：R573.3[医药卫生—消化系统] R442.1[医药卫生—内科学]