单纤维聚乙烯线缝合联合rb-bFGF对口腔颌面部外伤患者表皮生长因子及口腔功能的影响  

Effect of single fiber polyethylene suture combined with rb-bFGF on serum epidermal growth factor and oral function in patients with oral and maxillofacial trauma

作　　者：向琳 冉碧红 吕成鹏 任战平[4] Xiang Lin;Ran Bihong;Lyu Chengpeng;Ren Zhanping(Department of Stomatology,Xunyang People's Hospital,Ankang 725700,China;Department of Stomatology,Hantai District Maternal and Child Health Hospital,Hanzhong 723000,China;Department of Implant Dentistry,College of Stomatology,Xi'an Jiaotong University,Xi'an 710004,China;Department of Cleft Lip and Palate Surgery,College of Stomatology,Xi'an Jiaotong University,Xi'an 710004,China)

机构地区：[1]旬阳市人民医院口腔科,安康725700 [2]汉中市汉台区妇幼保健院口腔科,汉中723000 [3]西安交通大学口腔医院种植科,西安710004 [4]西安交通大学口腔医院唇腭裂外科,西安710004

出　　处：《国际医药卫生导报》2025年第2期293-297,共5页International Medicine and Health Guidance News

基　　金：陕西省重点研发计划(2018SF-118);陕西省重点研发计划(2019SF-161);陕西省重点研发计划(2024SF-YBXM-262)。

摘　　要：目的探讨单纤维聚乙烯线缝合联合重组牛碱性成纤维细胞生长因子(recombinant bovine basic fibroblast growth factor,rb-bFGF)对口腔颌面部外伤患者血清表皮生长因子(epidermal growth factor,EGF)及口腔功能的影响。方法本研究采用回顾性分析,选取2020年7月至2023年6月旬阳市人民医院收治的120例颌面部外伤患者,按治疗方法不同分为干预组[60例,男39例、女21例,年龄(35.54±2.61)岁]与传统组[60例,男36例,女34例,年龄(36.63±2.54)岁]。传统组采用单纤维聚乙烯线缝合治疗,干预组采用单纤维聚乙烯线缝合联合rb-bFGF治疗。比较两组临床疗效、治疗前后血清EGF水平与口腔功能(语言清晰度、咀嚼功能评分)、治疗满意度及安全性。采用t检验、方差分析、χ2检验进行统计比较。结果干预组总有效率为93.33%(56/60),传统组总有效率为73.33%(44/60),两组比较差异有统计学意义(P<0.05)。治疗后5 d,传统组血清EGF水平比较,差异无统计学意义(P>0.05);干预组血清EGF水平比较,差异有统计学意义(P<0.05);且干预组血清EGF水平均高于传统组(均P<0.05)。治疗后5 d,干预组语言清晰度、咀嚼功能评分均优于传统组(均P<0.05)。干预组治疗满意度为90.00%(54/60),传统组为66.67%(40/60),两组比较差异有统计学意义(P<0.05)。传统组、干预组不良反应发生率分别为10.00%(6/60)和13.33%(8/60),两组比较差异无统计学意义(P>0.05)。结论单纤维聚乙烯线缝合联合rb-bFGF对口腔颌面部外伤患者血清EGF水平及口腔功能可以产生积极影响,且安全性高。Objective To explore the effect of single fiber polyethylene suture combined with recombinant bovine basic fibroblast growth factor(rb-bFGF)on serum epidermal growth factor(EGF)and oral function in patients with oral and maxillofacial trauma.Methods This was a retrospective study.One hundred and twenty patients with maxillofacial trauma treated at Xunyang People's Hospital from July 2020 to June 2023 were selected,and were divided into an intervention group(60 cases)and a traditional group(60 cases)according to the treatment methods.There were 39 males and 21 females in the intervention group;they were(35.54±2.61)years old.There were 36 males and 34 females in the traditional group;they were(36.63±2.54)years old.The traditional group were treated with single fiber polyethylene suture,and the intervention group with single fiber polyethylene suture and rb-bFGF.The clinical efficacies,serum EGF levels and oral function(scores of speech intelligibility and masticatory function)before and after the treatment,treatment satisfaction,and safety were compared between the two groups.t test,analysis of variance,andχ2 test were used for the statistical comprisons.Results The total effective rate of the intervention group was higher than that of the traditional group[93.33%(56/60)vs.73.33%(44/60)],with a statistical difference between the two groups(P<0.05).There was no statistical difference in the serum EGF level between 5 d after the treatment in the traditional group(P>0.05),but was in the intervention group(P<0.05).5 d after the treatment,the serum EGF levels in the intervention group were higher than those in the control group(both P<0.05).Five days after the treatment,the scores of speech intelligibility and masticatory function in the intervention group were better than those in the traditional group(both P<0.05).The treatment satisfaction in the intervention group was higher than that of the traditional group[90.00%(27/30)vs.66.67%(20/30)],with a statistical difference between the two groups(P<0.05).There was no

关 键 词：外伤 口腔颌面部 单纤维聚乙烯线缝合 重组牛碱性成纤维细胞生长因子 表皮生长因子 口腔功能 

分 类 号：R782[医药卫生—口腔医学]