盐酸多奈哌齐联合丁苯酞治疗对血管性痴呆患者认知功能、痴呆程度的影响  

Effect of Donepezil Hydrochloride Combined with Butylphthalide on Cognitive Function and Degree of Dementia in Patients with Vascular Dementia

作　　者：李菲菲 LI Feifei(Department of Neurology,Linyi Mental Health Center,Linyi 276005,China)

机构地区：[1]临沂市精神卫生中心神经内科,山东临沂276005

出　　处：《反射疗法与康复医学》2024年第19期129-131,135,共4页Reflexology And Rehabilitation Medicine

摘　　要：目的探讨盐酸多奈哌齐联合丁苯酞治疗对血管性痴呆患者认知功能、痴呆程度的影响。方法选择临沂市精神卫生中心2023年1月—2024年1月收治的60例血管性痴呆患者为研究对象,按随机数字表法将其分为对照组和观察组,各30例。对照组采用盐酸多奈哌齐治疗,观察组在对照组的基础上联合丁苯酞治疗,两组均治疗3个月。比较两组的认知功能、临床疗效、痴呆程度、血液流变学指标、不良反应发生情况。结果观察组治疗总有效率为93.33%,高于对照组的73.33%,差异有统计学意义(P<0.05)。治疗后,观察组简易精神状态评定量表中各个维度评分均高于对照组,组间差异有统计学意义(P<0.05);两组临床痴呆程度量表评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组全血高切黏度、全血低切黏度及血浆黏度水平均低于对照组,组间差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论血管性痴呆患者予以盐酸多奈哌齐联合丁苯酞治疗可减轻其痴呆程度,改善其血液流变学指标,促进认知功能恢复,且安全性高。Objective To explore the effects of donepezil hydrochloride combined with butylphthalide on cognitive function and degree of dementia in patients with vascular dementia.Methods Selecting 60 patients with vascular dementia admitted to Linyi Mental Health Center from January 2023 to January 2024 as the research subjects,according to the random number table method,they were divided into a control group and an observation group,with 30 cases in each group.The control group was treated with donepezil hydrochloride,while the observation group was treated with combination therapy of butylphthalide on the basis of the control group,both groups were treated for 3 months.Compare the cognitive function,clinical efficacy,degree of dementia,hemorheological indicators and incidence of adverse reactions between two groups.Results The total effective rate of the observation gro up was 93.33%,which was higher than the 73.33%of the control group,the difference was statistically significant(P<0.05).After treatment,the scores of each dimension in the Mini-Mental State Examination of the observation group were higher than those of the control group,the differences between the groups were statistically significant(P<0.05);the Clinical Dementia Rating Scale scores of both groups were lower than those before treatment,and the observation group was lower than that in the control group,the difference was statistically significant(P<0.05);the levels of whole blood high shear viscosity,whole blood low shear viscosity and plasma viscosity in the observation group were lower than those in the control group,the differences between the groups were statistically significant(P<0.05).Comparison of incidence of adverse reactions between two groups,the difference was not statistically significant(P>0.05).Conclusion The donepezil hydrochloride combined with butylphthalide in patients with vascular dementia can alleviate the degree of dementia,improve hemorheological indicators,promote cognitive function recovery,and is highly safe.

关 键 词：血管性痴呆 盐酸多奈哌齐 丁苯酞 认知功能 痴呆程度 血液流变学指标 

分 类 号：R749.16[医药卫生—神经病学与精神病学]