薄荷酰胺/羟丙基-β-环糊精包合物的制备及其热缓释性能分析  

Preparation of menthol carboxamide/hydroxypropyl-β-cyclodextrin inclusion complex and its thermal sustained-release properties

作　　者：李倬 周当男 罗灿选 张智轩 宋伟民 陈泽少 艾丹 张晓平 郑峰洋 LI Zhuo;ZHOU Dangnan;LUO Canxuan;ZHANG Zhixuan;SONG Weimin;CHEN Zeshao;AI Dan;ZHANG Xiaoping;ZHENG Fengyang(Technology Center,China Tobacco Henan Industrial Co.,Ltd.,Zhengzhou 450016,China;Tobacco Science,Henan Agricultural University,Flavors and Fragrance Engineering&Technology Research Center of Henan Province,Zhengzhou 450046,China)

机构地区：[1]河南中烟工业有限责任公司技术中心,河南郑州450016 [2]河南农业大学烟草学院河南省香精香料与调香工程技术研究中心,河南郑州450046

出　　处：《应用化工》2024年第11期2539-2545,共7页Applied Chemical Industry

基　　金：国家自然科学基金(21801064);河南中烟工业有限责任公司技术开发分公司科技项目(AW2022021)。

摘　　要：以薄荷酰胺为芯材,β-环糊精和羟丙基-β-环糊精为壁材,采用共沉淀法、冷冻干燥法制备出两种包合物,并探究其在常温与高温条件下的缓释性能。结合粉末X射线衍射、扫描电镜、傅里叶红外光谱对包合物的结构、形貌及物质组成进行表征,使用热重分析仪对其热稳定性进行分析;并用紫外分光光度法测定了包合物的包埋率和不同温度下的缓释性。结果表明,薄荷酰胺/羟丙基-β-环糊精包合物的包埋率为12.31%,高于薄荷酰胺/β-环糊精包合物的包埋率(9.55%);两种包合物的热解温度均超过300℃,远高于薄荷酰胺的热解温度(217℃),包合物热稳定较好,薄荷酰胺/HP-β-环糊精在25~120℃下释放一定时间后,累计释放量仅为14.94%~40.06%,具有良好的缓释性能。Using menthol carboxamide as core material,β-cyclodextrin and hydroxypropylβ-cyclodextrin as wall material,two inclusion compounds were prepared by co-precipitation and freeze-drying method,and their slow release properties at room temperature and high temperature were investigated.The structure,morphology and composition of the inclusion compounds were characterized by powder X-ray diffraction,scanning electron microscopy and Fourier infrared spectroscopy.The thermal stability of the inclusion compound was analyzed by thermogravimetric analyzer.The inclusion rate and slow release properties of the inclusion compounds at different temperatures were determined by UV spectrophotometry.The results showed that the inclusion rate of menthol carboxamide/hydroxypropyl-β-cyclodextrin complex was 12.31%,which was higher than that of menthol carboxamide/β-cyclodextrin complex(9.55%).The pyrolysis temperature of the two inclusion compounds exceeds 300℃,which is much higher than that of menthol carboxamide(217℃).The inclusion compounds showed good thermal stability.After released at 25~120℃for a certain time,the cumulative release amount of menthol carboxamide/HP-β-cyclodextrin is only 14.94%~40.06%.The result exhibited that menthol carboxamide/HP-β-cyclodextrin showed good slow release performance.

关 键 词：羟丙基-Β-环糊精 薄荷酰胺 包合物 缓释 

分 类 号：TQ317[化学工程—高聚物工业] TS202.3[轻工技术与工程—食品科学]