草酸艾司西酞普兰与氢溴酸伏硫西汀治疗首发抑郁症临床疗效分析  

Clinical Efficacy of Escitalopram Oxalate and Vortioxetine Hydrobromide in Treatment of First-episode Depression

作　　者：焦丽梅[1] JIAO Li-mei(Second Department of Neurology,The Fourth Hospital of Handan City,Handan,Hebei 056200,China)

机构地区：[1]河北省邯郸市第四医院神内二科,河北邯郸056200

出　　处：《河北北方学院学报(自然科学版)》2025年第2期48-50,54,共4页Journal of Hebei North University:Natural Science Edition

摘　　要：目的探讨草酸艾司西酞普兰与氢溴酸伏硫西汀治疗首发抑郁症的临床疗效与不良反应发生情况。方法70例首发抑郁症患者按照随机数字表法分为草酸艾司西酞普兰组与氢溴酸伏硫西汀组各35例,草酸艾司西酞普兰组予以草酸艾司西酞普兰口服,氢溴酸伏硫西汀组予以氢溴酸伏硫西汀口服。应用汉密尔顿抑郁量表-24(Hamilton Depression Scale-24,HAMD-24)、抑郁症症状快速自评量表(Quick Inventory of Depressive Symptomatology 16-Item Self Report,QIDS-SR16)和蒙哥马利抑郁评定量表(Montogomery Depression Rating Scale,MADRS)评估患者治疗前及治疗2、4、8周后抑郁情况。结果治疗前2组患者HAMD-24、QIDS-SR16和MADRS评分比较差异无统计学意义(P>0.05)。治疗2、4、8周后2组患者HAMD-24、QIDS-SR16和MADRS评分均较治疗前下降(P<0.05),且随治疗后时间推进,评分下降差异有统计学意义(P<0.05);治疗后同一时间点组间比较差异无统计学意义(P>0.05)。艾司西酞普兰恶心、头痛、嗜睡等不良反应发生率高于氢溴酸伏硫西汀组,差异有统计学意义(P<0.05)。结论草酸艾司西酞普兰与氢溴酸伏硫西汀治疗首发抑郁症均有显著疗效,但氢溴酸伏硫西汀不良反应更少,安全性更高。Objective To investigate the clinical efficacy and adverse reactions of escitalopram oxalate and vortioxetine hydrobromide in the treatment of first-episode depression.Methods A total of 70 patients with first-episode depression were divided into escitalopram oxalate group and vortioxetine hydrobromide group according to random number table method,with 35 cases in each group.Escitalopram group was given escitalopram orally,and vortioxetine hydrobromide group was given vortioxetine hydrobromide orally.The Hamilton Depression Scale-24(HAMD-24),the Quick Inventory of Depressive Symptomatology 16-Item Self-Report(QIDS-SR16)and the Montgomery Depression Rating Scale(MADRS)were used to evaluate the depression of patients before treatment and 2,4 and 8 weeks after treatment.Results There was no significant difference in HAMD-24,QIDS-SR16 and MADRS scores between the two groups before treatment(P>0.05).The scores of HAMD-24,QIDS-SR16 and MADRS in the two groups at 2,4 and 8 weeks after treatment were lower than those before treatment(P<0.05),and the scores decreased with the time after treatment(P<0.05).There was no significant difference between the two groups at the same time point after treatment(P>0.05).The incidence of adverse reactions such as nausea,headache and somnolence in escitalopram group was higher than that in vortioxetine hydrobromide group,and the difference was statistically significant(P<0.05).Conclusion Both escitalopram oxalate and vortioxetine hydrobromide are effective in the treatment of first-episode depression,but vortioxetine hydrobromide has fewer adverse reactions and higher safety.

关 键 词：草酸艾司西酞普兰 氢溴酸伏硫西汀 汉密尔顿抑郁量表-24 抑郁症症状快速自评量表 蒙哥马利抑郁评定量表 

分 类 号：R749.4[医药卫生—神经病学与精神病学]