基于主观整体营养评估量表评分的营养干预对结直肠癌患者化疗期营养摄入和生活质量的影响  

Effects of nutritional intervention based on Patient-Generated Subjective Global Assessment score on nutritional intake and quality of life during chemotherapy in colorectal cancer patients

作　　者：邱换换 葛高琪 郭瑾 刘建芳 路亚婉 Qiu Huanhuan;Ge Gaoqi;Guo Jin;Liu Jianfang;Lu Yawan(Second Ward,Oncology Centre,Henan Provincial People's Hospital,Zhengzhou University People's Hospital,Zhengzhou 450000,China;Puyang Institute of Vocational Technology,Puyang 457000,China)

机构地区：[1]河南省人民医院郑州大学人民医院肿瘤中心二病区,郑州450000 [2]濮阳职业技术学院,濮阳457000

出　　处：《国际医药卫生导报》2025年第1期136-140,共5页International Medicine and Health Guidance News

基　　金：河南省科技厅科技攻关项目(222102310724)。

摘　　要：目的探究基于主观整体营养评估量表(PG-SGA)评分的营养干预对结直肠癌患者化疗期营养摄入和生活质量的影响。方法本研究为随机对照试验。选取2021年4月至2024年4月在河南省人民医院化疗的102例结直肠癌患者作为研究对象。采用随机数字表法,将患者分为对照组(51例)和观察组(51例)。对照组男30例,女21例;年龄(59.62±6.00)岁;肿瘤类型:结肠癌19例,直肠癌31例;临床分期:Ⅰ期12例,Ⅱ期20例,Ⅲ期19例。观察组男28例,女23例;年龄(59.45±6.18)岁;肿瘤类型:结肠癌16例,直肠癌35例;临床分期:Ⅰ期10例,Ⅱ期22例,Ⅲ期19例。对照组采用常规营养干预,观察组采用基于PG-SGA评分的营养干预。两组均干预至化疗周期结束。比较两组干预前后营养摄入情况(能量、蛋白质)、营养状况[血清白蛋白(ALB)、血红蛋白(Hb)、血清前白蛋白(PA)、血清总蛋白(TP)]、生活质量[生活质量综合评定问卷(GQOL-74)]。采用独立样本t检验、配对t检验和χ2检验进行统计学分析。结果干预后,观察组能量、蛋白质摄入量均高于对照组[(1110.78±256.90)kcal/d比(1001.23±231.78)kcal/d、(57.78±10.04)g/d比(43.15±9.26)g/d](均P<0.05);观察组ALB、Hb、PA、TP水平均高于对照组[(42.18±3.01)g/L比(39.00±2.89)g/L、(110.89±11.34)g/L比(105.28±11.00)g/L、(0.48±0.09)g/L比(0.33±0.07)g/L、(59.98±4.63)g/L比(55.17±4.38)g/L](均P<0.05);观察组GQOL-74中的躯体功能、社会功能、物质生活、心理功能评分均高于对照组[(70.12±6.53)分比(63.44±6.00)分、(67.19±6.82)分比(63.16±6.08)分、(73.22±7.03)分比(61.89±6.27)分、(71.26±7.90)分比(66.01±6.82)分](均P<0.05)。结论基于PG-SGA评分的营养干预可增加结直肠癌化疗期患者营养摄入,提高生活质量。Objective To investigate the effects of nutritional intervention based on Patient-Generated Subjective Global Assessment(PG-SGA)score on nutritional intake and quality of life during chemotherapy in colorectal cancer patients.Methods This study was a randomized controlled trial.A total of 102 patients with colorectal cancer who received chemotherapy in Henan Provincial People's Hospital from April 2021 to April 2024 were selected as the study objects.The patients were divided into a control group(51 cases)and an observation group(51 cases)by the random number table method.There were 30 males and 21 females in the control group,aged(59.62±6.00)years;the types of disease were colon cancer in 19 cases and rectal cancer in 31 cases;the clinical stages were stage Ⅰ in 12 cases,stage Ⅱ in 20 cases,and stage Ⅲ in 19 cases.There were 28 males and 23 females in the observation group,aged(59.45±6.18)years;the types of disease were colon cancer in 16 cases and rectal cancer in 35 cases;the clinical stages were stage Ⅰ in 10 cases,stage Ⅱ in 22 cases,stage Ⅲ in 19 cases.The control group received routine nutritional intervention,and the observation group received nutritional intervention based on PG-SGA score.Both groups were intervened until the end of the chemotherapy cycle.Nutritional intake(energy and protein),nutritional status[serum albumin(ALB),hemoglobin(Hb),serum prealbumin(PA),and serum total protein(TP)],and quality of life[Generic Quality of Life Inventory 74(GQOL-74)]were compared between the two groups before and after intervention.Independent sample t test,paired t test,and χ^(2) test were used for statistical analysis.Results After intervention,the energy intake and protein intake in the observation group were higher than those in the control group[(1110.78±256.90)kcal/d vs.(1001.23±231.78)kcal/d,(57.78±10.04)g/d vs.(43.15±9.26)g/d](both P<0.05).The levels of ALB,Hb,PA,and TP in the observation group were higher than those in the control group[(42.18±3.01)g/L vs.(39.00±2.89)g/L,(110.89±1

关 键 词：结直肠癌 化疗 主观整体营养评估量表 营养摄入 生活质量 

分 类 号：R735.34[医药卫生—肿瘤] R459.3[医药卫生—临床医学]