胃泌素释放肽前体、糖类抗原50、癌胚抗原与非小细胞肺癌患者临床特征及预后的关系  

Relationship between pro-gastrin-releasing peptide,carbohydrate antigen 50,carcinoembryonic antigen and clinical characteristic and prognosis of patients with non-small cell lung cancer

作　　者：赵帅 于瑞静 赵荣玲 ZHAO Shuai;YU Ruijing;ZHAO Rongling(Department of Laboratory,the Third People’sHospital of He’nan Province,Zhengzhou 450001,He’nan,China)

机构地区：[1]河南省直第三人民医院检验科,郑州4500010

出　　处：《癌症进展》2024年第23期2600-2603,共4页Oncology Progress

摘　　要：目的 探讨胃泌素释放肽前体(ProGRP)、糖类抗原50(CA50)、癌胚抗原(CEA)与非小细胞肺癌(NSCLC)患者临床特征及预后的关系。方法 选取104例NSCLC患者和80例健康体检者,分别作为NSCLC组和健康组,比较两组受试者及不同临床特征NSCLC患者的血清ProGRP、CA50、CEA水平。随访12个月,记录NSCLC患者的生存情况,采用Cox回归模型分析NSCLC患者预后的影响因素。结果 NSCLC组患者血清ProGRP、CA50、CEA水平均明显高于健康组,差异均有统计学意义(P<0.01)。临床分期为Ⅲ~Ⅳ期、有淋巴结转移、低分化NSCLC患者血清ProGRP、CA50、CEA水平均明显高于临床分期为Ⅰ~Ⅱ期、无淋巴结转移、中高分化患者,差异均有统计学意义(P<0.01)。多因素Cox回归分析结果显示,淋巴结转移、ProGRP水平≥123.22 pg/ml、CEA水平≥47.82 ng/ml均是NSCLC患者预后不良的独立危险因素(P<0.05)。结论 NSCLC患者血清ProGRP、CA50、CEA水平均较高,淋巴结转移、ProGRP水平≥123.22 pg/ml、CEA水平≥47.82 ng/ml均是NSCLC患者预后不良的独立危险因素。Objective To explore the relationship between pro-gastrin-releasing peptide(ProGRP),carbohydrate anti-gen 50(CA50),carcinoembryonic antigen(CEA)and clinical characteristics and prognosis of patients with non-small cell lung cancer(NSCLC).Method A total of 104 NSCLC patients and 80 healthy subjects were selected as NSCLC group and healthy group,respectively.The serum ProGRP,CA50 and CEA levels in the two groups and NSCLC patients with different clinical characteristics were compared.Followed up for 12 months,the survival of NSCLC patients was record-ed,and Cox regression model was used to analyze the influencing factors for prognosis of NSCLC patients.Result The levels of serum ProGRP,CA50 and CEA in NSCLC group were significantly higher than those in healthy group,and the differences were statistically significant(P<0.01).The levels of serum ProGRP,CA50 and CEA in NSCLC patients with clinical stage III-IV,lymph node metastasis and low differentiation were significantly higher than those in patients with clinical stage I-II,no lymph node metastasis and medium-high differentiation,and the differences were statistically signif-icant(P<0.01).Multivariate Cox regression analysis showed that lymph node metastasis,ProGRP level≥123.22 pg/ml and CEA level≥47.82 ng/ml were independent risk factors for poor prognosis in NSCLC patients(P<0.05).Conclusion The serum ProGRP,CA50 and CEA levels are higher in NSCLC patients,and lymph node metastasis,ProGRP levels≥123.22 pg/ml and CEA levels≥47.82 ng/ml are independent risk factors for poor prognosis in NSCLC patients.

关 键 词：非小细胞肺癌 胃泌素释放肽前体 糖类抗原50 癌胚抗原 临床特征 预后 

分 类 号：R734.2[医药卫生—肿瘤]