术中神经导航显微切除术在脑胶质瘤患者中的应用效果  

Application effect of intraoperative neuro navigation microsurgical resection in patients with glioma

作　　者：杨永飞 聂向飞 王帮庆 尹凯[1] 左玉超[1] YANG Yongfei;NIE Xiangfei;WANG Bangqing;YIN Kai;ZUO Yuchao(Department of Neurosurgery,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,He’nan,China)

机构地区：[1]郑州大学第一附属医院神经外科,郑州4500000

出　　处：《癌症进展》2024年第23期2612-2615,共4页Oncology Progress

基　　金：河南省医学科技攻关计划省部共建重点项目(SBGJ202102128)。

摘　　要：目的探讨术中神经导航显微切除术在脑胶质瘤患者中的应用效果。方法依据是否应用术中神经导航将110例脑胶质瘤患者分为导航组(n=52)和常规组(n=58),常规组患者接受常规显微切除术,导航组患者接受术中神经导航显微切除术。比较两组患者的肿瘤切除情况、血清因子指标[转化生长因子-β(TGF-β)、胶质纤维酸性蛋白(GFAP)、血管内皮生长因子(VEGF)]、生活质量[卡氏功能状态(KPS)评分]、神经功能[美国国立卫生研究院卒中量表(NIHSS)评分]、并发症发生情况及随访1年生存情况。结果导航组患者肿瘤切除情况优于常规组,差异有统计学意义(P<0.05)。术后7天,两组患者GFAP、VEGF、TGF-β水平均低于本组术前,导航组患者GFAP、VEGF、TGF-β水平均低于常规组,差异均有统计学意义(P<0.05)。术后3个月,两组患者NIHSS评分均低于本组术前,KPS评分均高于本组术前,导航组患者NIHSS评分低于常规组,KPS评分高于常规组,差异均有统计学意义(P<0.05)。两组患者的并发症总发生率和1年生存率比较,差异均无统计学意义(P>0.05)。结论术中神经导航显微切除术治疗脑胶质瘤的疗效显著,可提高肿瘤切除情况,改善生活质量和神经功能,且安全性较高。Objective To explore the application effect of intraoperative neuro navigation microsurgical resection in patients with glioma.Method A total of 110 glioma patients were divided into navigation group(n=52)and convention-al group(n=58)based on whether intraoperative neuro navigation was applied.Patients in the conventional group under-went conventional microsurgical resection,while patients in the navigation group underwent intraoperative neuro naviga-tion microsurgical resection.The tumor resection status,serum factor indicators[transforming growth factor-β(TGF-β),vascular endothelial growth factor(VEGF),glial fibrillary acidic protein(GFAP)],quality of life[Karnofsky performance status(KPS)score],neurological function[National Institutes of Health stroke scale(NIHSS)score],incidence of compli-cations,and 1-year follow-up survival were compared between the two groups.Result The tumor resection status in the navigation group was better than that in the conventional group,and the difference was statistically significant(P<0.05).Seven days after surgery,the levels of GFAP,VEGF,and TGF-βin both groups were lower than those before surgery,the levels of GFAP,VEGF,and TGF-βin navigation group were lower than those in the conventional group,and the differ-ences were statistically significant(P<0.05).Three months after surgery,the scores of NIHSS in both groups were lower than those before surgery,the scores of KPS were higher than those before surgery,the score of NIHSS in navigation group was lower than that in conventional group,the score of KPS was higher than that in conventional group,and the dif-ferences were statistically significant(P<0.05).There were no statistically significant differences in the total incidence of complications and 1-year survival rate between the two groups(P>0.05).Conclusion The efficacy of intraoperative neu-ro navigation microsurgical resection in the treatment of glioma is significant,which can improve tumor resection,en-hance quality of life and neurological function,and has high saf

关 键 词：术中神经导航显微切除术 常规显微切除术 脑胶质瘤 肿瘤切除 

分 类 号：R739.41[医药卫生—肿瘤]