血清肿瘤坏死因子α刺激基因6蛋白和ⅩⅥ型胶原蛋白预测溃疡性结肠炎患者预后的价值  

Values of serum tumor necrosis factor-α stimulated gene 6 protein and type ⅩⅥ collagen in predicting prognosis of patients with ulcerative colitis

作　　者：孟利军 张兰芳[1] 秦蕾[1] 李文静 申培君 陈旭 郭晓鹤[1] MENG Lijun;ZHANG Lanfang;QIN Lei;LI Wenjing;SHEN Peijun;CHEN Xu;GUO Xiaohe(Department of Gastroenterology,the First Affiliated Hospital of Xinxiang Medical University,Xinxiang,Henan,453100)

机构地区：[1]新乡医学院第一附属医院消化内科,河南新乡453100

出　　处：《实用临床医药杂志》2024年第23期87-90,95,共5页Journal of Clinical Medicine in Practice

基　　金：河南省医学科技攻关计划项目(LHGJ20210539)。

摘　　要：目的分析血清肿瘤坏死因子α刺激基因6蛋白(TSG-6)、ⅩⅥ型胶原蛋白(col-16)预测溃疡性结肠炎(UC)患者预后的价值。方法选取160例UC患者为UC组,另选取160例志愿者为对照组,比较2组血清TSG-6、col-16水平。参照改良Mayo评分标准将UC组患者分为轻度组(n=63)、中度组(n=52)、重度组(n=45),比较3组血清TSG-6、col-16水平。根据肠镜复查结果将UC组患者分为预后良好组(n=121)和预后不良组(n=39),比较2组血清TSG-6、col-16水平。采用Spearman相关性分析法探讨血清TSG-6、col-16与改良Mayo评分的相关性;采用Logistic回归分析法探讨血清TSG-6、col-16对UC组患者预后的影响;采用受试者工作特征(ROC)曲线评估血清TSG-6、col-16预测UC组患者预后的价值。结果UC组血清TSG-6、col-16水平高于对照组,差异有统计学意义(P<0.01)。中度组、重度组血清TSG-6、col-16水平高于轻度组,重度组血清TSG-6、col-16水平高于中度组,差异均有统计学意义(P<0.01)。预后不良组血清TSG-6、col-16水平高于预后良好组,差异有统计学意义(P<0.01)。Spearman相关性分析结果显示血清TSG-6、col-16与改良Mayo评分均呈正相关性(r=0.691,P<0.05;r=0.635,P<0.05)。Logistic分析结果显示血清TSG-6、col-16均是预后不良的危险因素(P<0.001)。ROC曲线分析显示,血清TSG-6、col-16预测UC组患者预后不良的曲线下面积分别为0.773、0.765。结论UC患者血清TSG-6、col-16呈异常升高状态,且与患者病情严重程度及预后存在一定的相关性,可作为预后不良的预测指标。Objective To analyze the values of serum tumor necrosis factor-αstimulated gene 6 protein(TSG-6)and type ⅩⅥ collagen(col-16)in predicting the prognosis of patients with ulcerative colitis(UC).Methods A total of 160 patients with UC were enrolled as UC group,another 160 volunteers were selected as control group,and the levels of serum TSG-6 and col-16 were compared between the two groups.According to the modified Mayo scoring criteria,patients in the UC group were divided into mild group(n=63),moderate group(n=52),and severe group(n=45),and the levels of serum TSG-6 and col-16 were compared among the three groups.Based on the colonoscopy follow-up results,patients in the UC group were divided into good prognosis group(n=121)and poor prognosis group(n=39),and the levels of serum TSG-6 and col-16 were compared between the two groups.Spearman correlation analysis was used to explore the correlations of serum TSG-6 and col-16 with the modified Mayo score.Logistic regression analysis was used to investigate the impact of serum TSG-6 and col-16 on the prognosis of patients in the UC group.Receiver operating characteristic(ROC)curve was used to assess the values of serum TSG-6 and col-16 in predicting the prognosis of patients in the UC group.Results The levels of serum TSG-6 and col-16 in the UC group were significantly higher than those in the control group(P<0.01).The levels of serum TSG-6 and col-16 in the moderate and severe groups were significantly higher than those in the mild group,and the levels of serum TSG-6 and col-16 in the severe group were significantly higher than those in the moderate group(P<0.01).The levels of serum TSG-6 and col-16 in the poor prognosis group were significantly higher than those in the good prognosis group(P<0.01).Spearman correlation analysis showedthat serum TSG-6 and col-16 were positively correlated with the modified Mayo score(r=0.691,P<0.05;r=0.635,P<0.05).Logistic analysis results showed that serum TSG-6 and col-16 were risk factors for poor prognosis(P<0.001).ROC curve a

关 键 词：肿瘤坏死因子α刺激基因6蛋白 ⅩⅥ型胶原蛋白 溃疡性结肠炎 预后 相关性 预测价值 

分 类 号：R574.62[医药卫生—消化系统] R446.11[医药卫生—内科学] R319[医药卫生—临床医学]