一种用于动脉粥样硬化靶向治疗的货物转换纳米材料制备  

Preparation of Cargo Conversion Nanomaterials for Targeted Therapy of Atherosclerosis

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作  者:杨潇 付钦瑞 李培峰[1] YANG Xiao;FU Qin-rui;LI Pei-feng(Institute for Translational Medicine,Qingdao University,Qingdao 266021,China)

机构地区:[1]青岛大学转化医学研究院,青岛266021

出  处:《青岛大学学报(自然科学版)》2024年第4期1-7,共7页Journal of Qingdao University(Natural Science Edition)

基  金:国家自然科学基金重大研究计划综合项目(批准号:92249303)资助。

摘  要:为探究同时针对动脉粥样硬化的内膜异常脂质沉积和炎症细胞聚集两种特征的治疗方法,通过主客体自组装方式,设计制备了β-环糊精-雷帕霉素纳米材料。体外利用竞争性结合实验,检测β-环糊精对雷帕霉素及胆固醇的亲和力;诱导小鼠单核巨噬细胞成炎症细胞,体外检测β-环糊精-雷帕霉素纳米材料对炎症细胞的抗炎效果及胆固醇清除效果。研究显示,β-环糊精对胆固醇的亲和能力高于雷帕霉素;β-环糊精与胆固醇结合同时释放雷帕霉素,能够实现联合治疗动脉粥样硬化。β-cyclodextrin-rapamycin nanomaterials were designed and prepared by host-guest self-assembly to explore a therapeutic approach targeting both abnormal lipid deposition and inflammatory cell aggregation in the intima of atherosclerosis.The affinity of β-cyclodextrin to rapamycin and cholesterol was tested by competitive binding assay in vitro.At the same time,RAW 264.7 cells were induced to become inflammatory cells,and the anti-inflammatory and cholesterol scavenging effects of β-cyclodextrin-rapamycin nanomaterial on inflammatory cells were detected in vitro.Studies show thatβ-cyclodextrin has a higher affinity for cholesterol than rapamycin.β-cyclodextrin binds to cholesterol and simultaneously releases rapamycin,which can realize the combined treatment of atherosclerosis.

关 键 词:Β-环糊精 雷帕霉素 动脉粥样硬化 胆固醇 

分 类 号:R542.2[医药卫生—心血管疾病]

 

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