微脉冲激光治疗重度放射性视网膜病变1例报告  

A case report of subthreshold micropulse laser treatment in severe radiation retinopathy

作　　者：胡云燕 张洪洋 覃泳杰[1] HU Yunyan;ZHANG Hongyong;QIN Yongjie(Guangdong Eye Institute,Department of Ophthalmology,Guangdong Provincial People′s Hospital(Guangdong Academy of Medical Sciences),Southern Medical University,Guangzhou 510080,Guangdong,China;Department of Ophthalmology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,Guangdong,China)

机构地区：[1]广东省眼病防治研究所,南方医科大学附属广东省人民医院(广东省医学科学院)眼科,广东广州510080 [2]南方医科大学南方医院眼科,广东广州510515

出　　处：《暨南大学学报(自然科学与医学版)》2024年第6期604-610,共7页Journal of Jinan University(Natural Science & Medicine Edition)

基　　金：国家自然科学基金项目(82471083;82171036);广东省自然科学基金项目(2023A1515011735)。

摘　　要：放射性视网膜病变(radiation retinopathy,RR)主要的治疗方式是玻璃体腔注射抗血管内皮生长因子(anti-vascular endothelial growth factor,anti-VEGF),但该方法成本高且需重复给药。目前RR的治疗尚无统一的标准,本文报告广东省人民医院2018年1例anti-VEGF治疗不佳、利用577 nm微脉冲激光成功消退因鼻咽癌放疗后所致的重度黄斑水肿病例,该患者的疗效稳定,随访5年尚未复发。采用微脉冲激光治疗RR黄斑水肿国内尚未见报道,结合文献对该病例进行分析讨论,认为微脉冲激光治疗具有成本低、无创、可重复操作的优点,可为RR的治疗提供新的策略。Radiation retinopathy(RR)is primarily treated with intravitreal injections of anti-vascular endothelial growth factor(anti-VEGF),which is costly and requires repeated administration.Currently,there is no unified standard for the treatment of RR.This paper reports a case where anti-VEGF therapy was ineffective in Guangdong Provincial People′s Hospital in 2018,but 577 nm subthreshold micropulse laser(SML)treatment successfully resolved the severe macular edema caused by radiotherapy for nasopharyngeal carcinoma,with stable therapeutic effects maintained over a 5-year follow-up period without recurrence.There have been no domestic reports on the use of SML treatment for RR macular edema.By reviewing the existing literature,SML is considered to be a cost-effective and non-invasive,allowing for repeatable procedures,it can provide a new strategy for the treatment of RR.

关 键 词：放射性视网膜病变 黄斑水肿 玻璃体腔注药 微脉冲激光 

分 类 号：R774.1[医药卫生—眼科]