泻心导赤散加味联合西药治疗心脾积热型复发性口腔溃疡临床研究  

Clinical Study on Modified Xiexin Daochi Powder Combined with Western Medicine for Recurrent Oral Ulcer of Accumulated Heat in Heart and Spleen Type

作　　者：郑岩兵 章才博 ZHENG Yanbing;ZHANG Caibo(Department of Stomatology,Yuhuan Haicheng Oral Outpatient Department,Yuhuan Zhejiang 317604,China;Department of Chinese Medicine,Western Medicine Nephrology Hospital of YuHuan,Yuhuan Zhejiang 317600,China)

机构地区：[1]玉环海成口腔门诊部口腔科,浙江玉环317604 [2]玉环中西医肾病医院中医科,浙江玉环317600

出　　处：《新中医》2025年第1期28-31,共4页New Chinese Medicine

摘　　要：目的:观察泻心导赤散加味联合西药治疗心脾积热型复发性口腔溃疡(ROU)的临床疗效。方法:采用随机数字表法将2020年6月—2023年4月玉环海成口腔门诊部收治的82例心脾积热型ROU患者分为观察组与对照组各41例。对照组给予常规西药治疗,观察组在对照组基础上加用泻心导赤散加味治疗。2组均连续治疗2周。比较2组治疗前后中医证候评分、视觉模拟评分法(VAS)评分、溃疡直径、免疫功能指标以及血清肿瘤坏死因子(TNF)-α和白细胞介素(IL)-6水平,评估2组临床疗效、疾病复发情况。结果:治疗后,观察组总有效率高于对照组(P<0.05)。治疗后,2组中医证候评分、VAS评分、溃疡直径及CD8^(+)、TNF-α和IL-6水平均较治疗前降低,CD3^(+)、CD4^(+)水平升高(P<0.05),且观察组中医证候评分、VAS评分、溃疡直径及CD8^(+)、TNF-α和IL-6水平低于对照组,CD3^(+)、CD4^(+)水平高于对照组(P<0.05)。观察组疾病复发率4.76%(1/21),低于对照组42.86%(6/14)(P<0.05)。结论:泻心导赤散加味联合西药治疗心脾积热型ROU疗效确切,能够减轻患者疼痛,提高免疫功能,降低炎症反应及疾病复发率。Objective:To observe the clinical effect of modified Xiexin Daochi Powder combined with western medicine on recurrent oral ulcer(ROU)of accumulated heat in heart and spleen type.Methods:A total of 82 patients with ROU of accumulated heat in heart and spleen type admitted to Yuhuan Haicheng Oral Outpatient Department from June 2020 to April 2023 were divided into the control group and the observation group by the random number table method,with 41 cases in each group.The control group was given conventional western medicine treatment,and the observation group was treated with modified Xiexin Daochi Powder on basis of the conventional treatment.Both groups were treated continuously for two weeks.The traditional Chinese medicine(TCM)syndrome scores,Visual Analogue Scale(VAS)scores,ulcer diameters,immune function indicators,and levels of serum tumor necrosis factor(TNF)-αand interleukin(IL)-6 were compared before and after treatment in the two groups;the clinical efficacy and disease recurrence were evaluated.Results:After treatment,the total effective rate in the observation group was higher than that in the control group(P<0.05).After treatment,TCM syndrome scores,VAS scores,ulcer diameters,and levels of CD8^(+),TNF-αand IL-6 in the two groups were decreased when compared with those before treatment,and the levels of CD3^(+)and CD4^(+)were increased(P<0.05);TCM syndrome score,VAS score,ulcer diameter,and the levels of CD8^(+),TNF-αand IL-6 in the observation group were lower than those in the control group,and the levels of CD3^(+)and CD4^(+)were higher(P<0.05).The recurrence rate in the observation group was 4.76%(1/21),lower than that of 42.86%(6/14)in the control group(P<0.05).Conclusion:The combination of modified Xiexin Daochi Powder and western medicine has a definite effect on ROU of accumulated heat in heart and spleen type,which can alleviate pain,improve immune function,and reduce the inflammatory responses and disease recurrence rate.

关 键 词：复发性口腔溃疡 心脾积热型 泻心导赤散 免疫功能 肿瘤坏死因子-Α 白细胞介素-6 

分 类 号：R781.5[医药卫生—口腔医学]