CA125、HE4及ROMA與絕經後子宮内膜癌臨床病理特徵的關係  

The relationship between serum CA125,HE4 levels,ROMA index and clinicopathological characteristics of postmenopausal women with endometrial cancer

作　　者：李純科 洪宇 梁海琪 陳清葉 宋粵玲 薛穎文 LI Chun Ke;HONG Yu;LIANG Hai Qi;CHEN Qing Ye;SONG Yue Ling;XUE Ying Wen(Department of Obstetrics and Gynecology,Kiang Wu Hospital,Macao,China)

机构地区：[1]澳門鏡湖醫院婦產科,中國澳門

出　　处：《镜湖医学》2024年第2期21-24,共4页MEDICAL JOURNAL OF KIANG WU

基　　金：澳門科學技術發展基金(0003/2022/A和0001/2024/RIA1)。

摘　　要：目的探討血清糖類抗原125(CA125)、血清人附睾蛋白-4(HE4)水準及卵巢癌惡性風險模型指數(ROMA)與絕經後子宮内膜癌(EC)患者臨床病理特徵的關係。方法選取2016年6月~2022年9月間在本院婦產科住院行全面分期手術的絕經後EC患者,術前檢測患者血清CA125、HE4,並計算ROMA指數,詳細記錄臨床資料及術後病理結果。結果共納入絕經後EC患者57例,其中子宮内膜樣EC47例,非子宮内膜樣EC10例;子宮内膜樣EC患者CA125、HE4及ROMA指數與非子宮内膜樣EC患者相比,無明顯異常(P>0.05);子宮内膜樣EC患者中,CA125、HE4及ROMA隨腫瘤細胞分化的升級而升高,但差異無明顯統計學意義(P>0.05);CA125、HE4及ROMA在腫瘤浸潤肌層不同深度的患者之間無明顯異常(P均>0.05);存在脈管浸潤或淋巴結轉移的患者CA125、HE4及ROMA較陰性患者升高,但僅CA125及ROMA在淋巴結轉移與未轉移患者之間的差異有統計學意義(P<0.05)。結論血清CA125及ROMA指數與絕經後子宮内膜樣(EC)臨床病理特徵關係密切,可作為患者術前評估淋巴結轉移風險的輔助指標。Objective To explore the relationship between serum levels of CA125,HE4,and ROMA index and the clinicopathological characteristics of postmenopausal women with endometrial cancer(EC).Methods From June 2016 to September 2022,postmenopausal EC patients who underwent comprehensive staging surgery in the Department of Obstetrics and Gynecology,Kiang Wu Hospital,Macao were enrolled in this retrospective study.Preoperative serum levels of CA125 and HE4 were measured,and the ROMA index was calculated.Clinical materials and postoperative pathological results were recorded in detail.Results A total of 57 postmenopausal EC patients were enrolled,including 47 cases with endometrioid EC and 10 cases with non-endometrioid EC.There were no significant differences in CA125,HE4,and ROMA index in patients with endometrioid EC compared to non-endometrioid EC patients(P>0.05).In patients with endometrioid EC,CA125,HE4,and ROMA increased with the escalation of tumor cell differentiation,but the differences were not statistically significant(P>0.05).There were no significant differences in CA125,HE4,and ROMA among patients with different depths of myometrial invasion(P>0.05).Patients with lymphovascular space invasion or lymph node metastasis(LNM)showed higher levels of CA125,HE4,and ROMA compared to negative counterparts,but only the differences in CA125 and ROMA between LNM patients and non-LNM patients were statistically significant(P<0.05).Conclusion Serum CA125 and ROMA index can serve as auxiliary indicators for preoperative assessment of lymph node metastasis risk in postmenopausal patients with endometrioid EC.

关 键 词：血清糖類抗原125 血清人附睾蛋白-4 卵巢癌惡性風險模型指 子宮内膜癌 淋巴結轉移 

分 类 号：R73[医药卫生—肿瘤]