15例IgG4相關性疾病的臨床病理特徵  

IgG4-related disease:a clinicopathologic analysis of 15 cases

作　　者：肖剛 葉玉清 韋潔貞 冼麗芳 古杰鳴 XIAO Gang;YIP Yuk Ching;WAI Kit Cheng;SIN Lai Fong;KU Kit Meng(Department of Pathology,Kiang Wu Hospital,Macao,China)

机构地区：[1]澳門鏡湖醫院病理科,中國澳門

出　　处：《镜湖医学》2024年第2期29-30,24,共3页MEDICAL JOURNAL OF KIANG WU

摘　　要：目的探討IgG4相關性疾病(IgG4-related disease,IgG4-RD)的臨床病理特點,免疫表型,加強臨床和病理醫生對本病的認識。方法分析15例IgG4-RD的臨床特點及病理改變,並複習相關文獻。結果15例IgG4-RD平均年齡66歲,男女比7:3。發病部位分别為頜下腺(6例),腮腺(2例),淋巴結(5例),肺(1例)、睾丸(1例)。病理改變表現為間質硬化伴較多IgG4陽性的漿細胞浸潤。結論IgG4-RD是少見的疾病,無特異的臨床表現,明確診斷有賴於病理活檢和免疫組織化學。Objective To study the clinicopathologic features,and immunophenotype of IgG4-related disease(IgG4-RD),improve clinicians’and pathologists’understanding of this disease.Methods The clinical features and pathologic changes were observed and analyzed in 15 cases with IgG4-RD,and relevant literatures were reviewed.Results The mean age of the patients was 66 years.The male-to-female ratio was 7:3.The involved site were mainly the submandibular gland and lymph nodes,followed by the parotid gland,lung and testis.The main pathological changes are stromal sclerosis characterized by an increase in IgG4+plasma cells on immunostaining.Conclusion IgG4-RD,a rare disease,has no characteristic clinical manifestation.A definitive diagnosis depends on biopsy and immunohistochemistry.

关 键 词：IgG4相關性疾病 病理診斷 

分 类 号：R73[医药卫生—肿瘤]