液体活检在早期良恶性肺结节诊断中的研究进展  

Research progress of liquid biopsy in the diagnosis of pulmonary nodules

作　　者：吕超(综述) 汪小云(综述) 刘柳(综述) 魏大荣(综述) 牟方政(审校) LYU Chao;WANG Xiaoyun;LIU Liu;WEI Darong;MOU Fangzhen(Department of Traditional Chinese Medicine,Chongqing University Three Gorges Hospital,Chongqing 404100,China;Cancer Early Detection and Treatment Center,Chongqing University Three Gorges Hospital,Chongqing 404100,China;Chongqing Technical Innovation Center for Quality Evaluation and Identification of Authentic Medicinal Herbs,Chongqing 404100,China)

机构地区：[1]重庆大学附属三峡医院中医内科,重庆404100 [2]重庆大学附属三峡医院肿瘤早期诊治中心,重庆404100 [3]重庆市道地药材质量评价与鉴定技术创新中心,重庆404100

出　　处：《国际检验医学杂志》2025年第1期107-112,共6页International Journal of Laboratory Medicine

基　　金：重庆市万州区科卫联合医学科研项目(wzstc-kw2023039);重庆市科卫联合中医药科研项目(2024ZYQN001)。

摘　　要：在我国,肺癌居恶性肿瘤发病及死亡之首,早期诊治可显著提高肺癌的生存率,然而75%的患者在初诊时已处于晚期,错过最佳治疗时机。肺结节是早期肺癌的表现形式,如何精准区分良恶性肺结节,避免恶性肺结节的漏诊及良性肺结节的过度治疗是一直困扰临床的重要问题。液体活检具有无创、重复性高、可操作性强、易于动态监测及克服肿瘤异质性等优势,可实现对恶性肿瘤早发现、早诊断,是最具潜力的肿瘤精准医学检测技术,有望成为肺结节良恶性诊断的突破口。文章就近年来液体活检在肺结节诊断中的研究与应用作一综述,以期为其临床应用及未来研究提供思路。In China,lung cancer ranks first in the incidence and death of malignant tumors.Early diagnosis and timely treatment can significantly improve the survival rate of lung cancer.However,75%of patients are already in the advanced stage at the time of initial diagnosis,missing the best treatment opportunity.Lung nodules are the manifestations of early lung cancer.How to accurately distinguish benign and malignant pulmonary nodules and avoid missing diagnosis of malignant lung nodules and over-treatment of benign lung nodules are important clinical problems.Liquid biopsy has the advantages of non-invasiveness,high reproducibility,operability,easy dynamic monitoring and overcoming tumor heterogeneity,which can realize early detection and diagnosis of malignant tumors.Besides,it is the most potential precision tumor detection technology,which is expected to become a breakthrough in the diagnosis of benign and malignant lung nodules.This article reviews the research and application of liquid biopsy in the diagnosis of lung nodules in recent years,in order to provide ideas for clinical application and future research.

关 键 词：液体活检 肺结节 循环肿瘤细胞 循环肿瘤DNA 

分 类 号：R734.2[医药卫生—肿瘤]