缺血性脑卒中后并发静脉血栓栓塞的影响因素分析  

Analysis of influencing factors of venous thromboembolism after ischemic stroke

作　　者：杨宁 刘松 赵燕[2] 王旭 魏海峰[2] 魏雁虹[2] Yang Ning;Liu Song;Zhao Yan;Wang Xu;Wei Haifeng;Wei Yanhong(College of Clinical Medicine,Changchun University of Traditional Chinese Medicine,Changchun Jilin 130117,China;Jilin Province People’s Hospital,Changchun Jilin 130021,China)

机构地区：[1]长春中医药大学临床医学院,吉林长春130117 [2]吉林省人民医院,吉林长春130021

出　　处：《中国医刊》2025年第1期31-33,共3页Chinese Journal of Medicine

基　　金：吉林省卫生健康科技能力提升项目(2023LC049)。

摘　　要：目的探究缺血性脑卒中后并发静脉血栓栓塞(VTE)的影响因素。方法回顾性分析2020年1月至2022年6月吉林省人民医院收治的204例缺血性脑卒中患者的临床资料,根据是否并发VTE将研究对象分为VTE组(并发VTE,77例)和非VTE组(未并发VTE,127例)。采用单因素和多因素logistic回归方法分析缺血性脑卒中后并发VTE的独立影响因素。结果VTE组患者的饮酒史比例、合并高血压比例、卧床时间>3 d比例、同型半胱氨酸(Hcy)、D-二聚体(D-D)、美国国立卫生研究院卒中量表(NIHSS)评分、Caprini血栓风险评估量表评分均高于非VTE组,预防性应用抗凝药物比例、Barthel指数评分均低于非VTE组,差异均有统计学意义(P<0.05)。多因素logistic回归分析结果显示,合并高血压、Hcy≥15.00μmol/L、D-D≥0.55 g/L、NIHSS评分≥4分、Barthel指数评分≤60分均是缺血性脑卒中后并发VTE的独立危险因素(P<0.05),预防性应用抗凝药物是缺血性脑卒中后并发VTE的独立保护因素(P<0.05)。结论合并高血压、Hcy、D-D、NIHSS评分、Barthel指数评分以及预防性应用抗凝药物均与缺血性脑卒中后并发VTE显著相关。Objective To explore the infl uencing factors of venous thromboembolism(VTE)after ischmic stroke.Method The clinical data of 204 patients with ischemic stroke admitted to Jilin Provincial People’s Hospital from January 2020 to June 2022 were retrospectively analyzed.They were divided into VTE group(with VTE,77 cases)and non-VTE group(without VTE,127 cases)according to whether they were complicated with VTE.Univariate and multivariate logistic regression methods were used to analyze the independent infl uencing factors of VTE after ischemic stroke.Result The proportion of alcohol consumption history,the proportion combined with hypertension,the proportion of bed time>3 d,Hcy,D-D,NIHSS score,Caprini score in VTE group were higher than those in non-VTE group,and the proportion of prophylactic use of anticoagulants and Barthel index score were lower than those in the non-VTE group,with statistical significance(P<0.05).Multivariate logistic regression analysis shows that combined with hypertension,Hcy≥15.00μmol/L,D-D≥0.55 g/L,NIHSS score≥4 points,Barthel index score≤60 points were independent risk factors of VTE after ischemic stroke(P<0.05),and prophylactic use of anticoagulants was an independent protective factor of VTE after ischemic stroke(P<0.05).Conclusion Combined with hypertension,Hcy,D-D,NIHSS score,Barthel index score and prophylactic use of anticoagulants were signifi cantly associated with VTE after ischemic stroke.

关 键 词：缺血性脑卒中 静脉血栓栓塞 影响因素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]