B7-H3在小细胞肺癌中的表达及其与患者预后的关联性研究  

A study on B7-H3 expression in small-cell lung cancer and its correlation with the small-cell lung cancer patients′prognosis

作　　者：李曦[1] 李红霞 林海峰 王守正 张权[1] 吕嘉林[1] 李杰[1] 郑华[1] 胡瑛[1] LI Xi;LI Hongxia;LIN Haifeng;WANG Shouzheng;ZHANG Quan;LYU Jialin;LI Jie;ZHENG Hua;HU Ying(Department of Medical Oncology,Beijing Chest Hospital,Capital Medical University(Beijing Tuberculosis and Thoracic Tumor Research Institute),Beijing 101149,China;Department of Pathology,Beijing Chest Hospital,Capital Medical University(Beijing Tuberculosis and Thoracic Tumor Research Institute),Beijing 101149,China)

机构地区：[1]首都医科大学附属北京胸科医院(北京市结核病胸部肿瘤研究所)肿瘤内科,北京101149 [2]首都医科大学附属北京胸科医院(北京市结核病胸部肿瘤研究所)病理科,北京101149

出　　处：《中国临床新医学》2024年第12期1352-1356,共5页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

摘　　要：目的探讨B7-H3在小细胞肺癌(SCLC)中的表达水平及其与患者预后的关联性。方法收集2010年1月至2019年7月于首都医科大学附属北京胸科医院经外科手术切除的SCLC组织标本34份,并收集标本来源患者的病历资料和随访资料。采用免疫组化方法检测SCLC组织B7-H3的表达情况,并分析其表达水平与患者临床特征的关联性。结果B7-H3高表达14例(41.18%),B7-H3低表达20例(58.82%)。B7-H3表达阳性26例(76.47%),表达阴性8例(23.53%)。B7-H3高表达组淋巴结转移比例及淋巴结转移数目高于B7-H3低表达组,差异有统计学意义(P<0.05),两组性别、年龄、吸烟比例比较差异无统计学意义(P>0.05)。B7-H3表达与微血管密度(MVD)评分之间存在一致性(Kappa=0.339,P=0.048)。B7-H3高表达组MVD评分高于B7-H3低表达组,差异有统计学意义(t=3.784,P=0.001)。B7-H3高表达组的中位总生存期短于B7-H3低表达组(13.8个月vs 23.5个月),两组生存预后比较差异有统计学意义(log-rank检验:χ^(2)=3.873,P=0.049)。结论B7-H3在SCLC组织中有不同程度表达,B7-H3高表达与淋巴结转移、不良预后相关,有可能成为SCLC治疗的潜在靶标。Objective To explore the B7-H3 expression level in small-cell lung cancer(SCLC)and its correlation with the small-cell lung cancer patients′prognosis.Methods Thirty-four SCLC tissue specimens surgically resected in Beijing Chest Hospital,Capital Medical University from January 2010 to July 2019 were collected,and the medical records and follow-up data of the patients from whom the specimens were obtained were collected.The expression of B7-H3 in the SCLC tissues was detected by using immunohistochemical method,and the correlation between the expression level of B7-H3 in the SCLC tissues and the patients′clinical characteristics was analyzed.Results There were 14 patients(41.18%)with high expression of B7-H3 and 20 patients(58.82%)with low expression of B7-H3.The expression of B7-H3 was positive in 26 cases(76.47%)and negative in 8 cases(23.53%).The proportion of lymph node metastasis and the number of lymph node metastasis in the high B7-H3 expression group were higher than those in the low B7-H3 expression group,and the differences were statistically significant(P<0.05).However,there were no statistically significant differences in gender,age and smoking ratio between the two groups(P>0.05).Expression of B7-H3 was consistent with score of micro vessel density(MVD)(Kappa=0.339,P=0.048).The MVD scores of the high B7-H3 expression group were higher than those of the low B7-H3 expression group,and the differences were statistically significant(t=3.784,P=0.001).The median overall survival(OS)of the high B7-H3 expression group was shorter than that of the low B7-H3 expression group(13.8 months vs 23.5 months),and the difference in survival prognosis between the two groups was statistically significant(log-rank test:χ^(2)=3.873,P=0.049).Conclusion B7-H3 is expressed to varying degrees in SCLC tissues,and high expression of B7-H3 is associated with lymph node metastasis and poor prognosis,which may become a potential target for treatment of SCLC.

关 键 词：小细胞肺癌 B7-H3 预后 

分 类 号：R734.2[医药卫生—肿瘤]