金属氧化物型复合纳米材料的制备及应用  

Preparation and application of metal oxide-based composite nanomaterials

作　　者：修梦婷 郑之裕 王通 朱利民[1] Xiu Mengting;Zheng Zhiyu;Wang Tong;Zhu Limin(College of Biological Science and Medical Engineering,Donghua University,Shanghai 201620)

机构地区：[1]东华大学生物与医学工程学院,上海201620

出　　处：《化工新型材料》2025年第1期33-37,共5页New Chemical Materials

基　　金：上海市科学技术委员会资助(22520710400、21WZ2501300和20DZ2254900);生物医药纺织材料“111工程”中国教育部项目(B07024)。

摘　　要：首先以乙酰丙酮铁[Fe(C_(5)H_(7)O_(2))_(3),98%]、乙酰丙酮铜[Cu(C_(5)H_(7)O_(2))_(2),97%]、二缩三乙二醇(TEG)为原料制备小型双金属氧化物纳米颗粒(CuFe_(2)O_(4))。小型双金属氧化物纳米颗粒(CuFe_(2)O_(4))通过静电吸附作用负载在过氧化镁(MgO_(2))纳米片上以形成金属氧化物型复合纳米材料(CuFe_(2)O_(4)@MgO_(2))。该复合纳米材料在肿瘤酸性条件下能产生大量高毒性的羟基自由基(·OH),对肿瘤细胞有较大的损伤作用。采用透射电子显微镜(TEM)、X射线光电子能谱技术、Zeta电位等手段对复合纳米材料进行表征。结果表明:CuFe_(2)O_(4)纳米颗粒分布在过氧化镁(MgO_(2))纳米片的表面,同时结合Zeta电位等表征证明该复合纳米材料的成功制备。体外细胞实验证明该复合纳米材料具备抗肿瘤治疗效果。First,small bimetallic oxide nanoparticles(CuFe_(2)O_(4))were prepared from iron acetylacetonate[Fe(C_(5)H_(7)O_(2))_(3),98%],copper acetylacetonate[Cu(C_(5)H_(7)O_(2))_(2),97%],and triethylene glycol(TEG).The small bimetallic oxide nanoparticles(CuFe_(2)O_(4))were loaded on magnesium peroxide(MgO_(2))nanosheets by electrostatic adsorption to form metal oxide-based composite nanomaterials(CuFe_(2)O_(4)@MgO_(2)).The composite nanomaterials could produce a large number of highly toxic hydroxyl radicals(·OH)under acidic conditions in tumors,which had a large damaging effect on tumor cells.Transmission electron microscopy(TEM),XPS spectroscopy,and zeta potential were used to characterize the composite nanomaterials.The results showed that CuFe_(2)O_(4)nanoparticles were distributed on the surface of magnesium peroxide(MgO_(2))nanosheets,and zeta potential measurements confirmed the successful preparation of this composite nanomaterial.In vitro cellular experiments demonstrated that the composite nanomaterials possessed anti-tumor therapeutic effects.

关 键 词：金属氧化物 静电吸附作用 活性氧 肿瘤治疗 

分 类 号：TQ460.4[化学工程—制药化工] R730.53[医药卫生—肿瘤]