异质核糖核蛋白F在恶性肿瘤中的研究进展  

Research progress of heterogeneous ribonucleoprotein F in malignant neoplasms

作　　者：蒋宗赢 章聪 蒋新卫[1] JIANG Zongying;ZHANG Cong;JIANG Xinwei(Department of Hepatobiliary Surgery,the Affiliated Suzhou Hospital of Nanjing Medical University(Suzhou Municipal Hospital),Suzhou 215000,China)

机构地区：[1]南京医科大学附属苏州医院(苏州市立医院)肝胆外科,江苏苏州215000

出　　处：《南京医科大学学报(自然科学版)》2025年第1期111-118,共8页Journal of Nanjing Medical University(Natural Sciences)

基　　金：苏州市临床医学中心建设项目(Szlcyxzxj202107);苏州市基础研究计划-医学应用基础研究(SKYD2023141)。

摘　　要：异质核糖核蛋白F(heterogeneous nuclear ribonucleoprotein F,HNRNPF)是一种在细胞核中广泛表达的RNA结合蛋白,可通过识别结合特定的RNA序列使得mRNA前体成熟为功能性mRNA,调控mRNA的核转运和表达稳定,影响肿瘤相关信号通路。HNRNPF在多种恶性肿瘤中异常表达并与不良预后相关,参与肿瘤细胞增殖、侵袭和转移等关键生物学过程,可能成为潜在的治疗靶点和临床预后标志物。本文将系统性地综述HNRNPF的分子结构特点、分子功能、在恶性肿瘤中的表达模式、预后意义以及相关作用机制,以期为恶性肿瘤的诊断、治疗和预后评估提供新的思路。Heterogeneous nuclear ribonucleoprotein F(HNRNPF)is a widely expressed RNA-binding protein primarily localized in the nucleus.It plays a crucial role in the maturation of mRNA precursors,facilitating their conversion into functional mRNAs through the recognition and binding of specific RNA sequences.Additionally,it regulates mRNA nuclear transport,enhances expression stability,and influences the transmission of tumor-related signaling pathways.HNRNPF exhibits abnormal expression in various malignant tumors and is strongly correlated with a poor prognosis.It actively participates in crucial biological processes including tumor cell proliferation,invasion,and metastasis,thereby potentially serving as both a therapeutic target and a clinical prognostic marker.This paper systematically reviews the molecular structure and function,expression patterns and prognostic implications of HNRNPF in malignant neoplasms,along with its associated mechanism of action,to generate novel insights for the neoplastic diagnosis,treatment,and prognosis.

关 键 词：异质核糖核蛋白F RNA结合蛋白 恶性肿瘤 分子功能 泛癌 

分 类 号：R730.23[医药卫生—肿瘤]