青中年缺血性脑卒中后信息处理速度减慢的危险因素分析  

Risk factors for slowing of information processing speed after ischemic stroke in young and middle⁃aged patients

作　　者：蒲荣梅 吴月 郭晓聪[2] 徐晓娅[1] 苏牟潇[3] PU Rongmei;WU Yue;GUO Xiaocong;XU Xiaoya;SU Mouxiao(Department of Neurology,The First People's Hospital of Zigong,Zigong,Sichuan 643000,China;Department of Clinical Laboratory,The First People's Hospital of Zigong,Zigong,Sichuan 643000,China;Department of Rehabilitation,Mianyang Central Hospital,Mianyang,Sichuan 621000,China)

机构地区：[1]自贡市第一人民医院神经内科,四川自贡643000 [2]自贡市第一人民医院检验科,四川自贡643000 [3]绵阳市中心医院康复科,四川绵阳621000

出　　处：《国际神经病学神经外科学杂志》2024年第6期23-28,共6页Journal of International Neurology and Neurosurgery

基　　金：四川省自然科学基金面上项目(2022NSFSC0798);四川省自贡市重点科技计划项目(2021YLSF05、2022CNKY08)。

摘　　要：目的探讨青中年缺血性脑卒中患者卒中后信息处理速度(IPS)减慢的发生率及危险因素。方法纳入2021年2月至2023年2月在自贡市第一人民医院神经内科住院确诊的青中年缺血性脑卒中急性期患者72例。收集受试者人口学资料、卒中相关信息及血管危险因素、影像学资料、实验室检查数据,在发病后2周时进行符号数字转换测验(SDMT)、简易智力状态检查量表(MMSE)、蒙特利尔认知评估(MoCA)测评,依据SDMT评分将受试者分为IPS正常组(30例)和IPS减慢组(42例)。采用多因素Logistic回归分析评估IPS减慢的危险因素。结果该研究的患者中,男性47例(65.3%)、女性25例(34.7%),平均年龄(54.28±6.14)岁。发病2周时出现IPS减慢42例(58.3%)。多因素Logistic回归分析显示,治疗前NIHSS评分较高(OR=2.381,95%CI=1.179~4.810,P<0.05),梗死部位为颞叶(OR=8.856,95%CI=1.433~54.748,P<0.05)、侧脑室旁(OR=10.083,95%CI=1.526~52.614,P<0.05)、岛叶(OR=19.528,95%CI=1.354~281.677,P<0.05),TOAST分型为小动脉闭塞型(OR=7.877,95%CI=1.526~40.656,P<0.05)是青中年缺血性脑卒中患者卒中后IPS减慢的危险因素。结论青中年缺血性脑卒中患者卒中后IPS减慢的发生率高;治疗前NIHSS评分高,梗死部位为颞叶、岛叶、侧脑室旁,TOAST分型为小动脉闭塞型的患者发生卒中后IPS减慢的风险更高。Objective To investigate the incidence rate of slowing of information processing speed(IPS)after ischemic stroke in young and middle-aged patients and related risk factors.Methods A total of 72 young and middle-aged patients in the acute stage of ischemic stroke who were hospitalized and diagnosed in Department of Neurology,The First People's Hospital of Zigong,from February 2021 to February 2023 were enrolled in this study.Related data were collected from all subjects,including demographic data,stroke data,vascular risk factors,imaging data,and laboratory examination data.Symbol Digit Modalities Test(SDMT),Mini-Mental State Examination(MMSE),and Montreal Cognitive Assessment(MoCA)were performed at 2 weeks after disease onset.According to the SDMT score,the subjects were divided into normal IPS group with 30 subjects and IPS slowing group with 42 subjects.A multivariate logistic regression analysis was used to investigate the risk factors for slowing of IPS.Results Among the subjects in this study,there were 47 males(65.3%)and 25 females(34.7%),with a mean age of(54.28±6.14)years.Slowing of IPS was observed in 42 pationts(58.3%)at 2 weeks after disease onset.The multivariate logistic regression analysis showed that a relatively high NIHSS score before treatment(OR=2.381,95%CI:1.179-4.810,P<0.05),the infarction site of the temporal lobe(OR=8.856,95%CI:1.433-54.748,P<0.05),the infarction site of the lateral ventricle(OR=10.083,95%CI:1.526-52.614,P<0.05),the infarction site of the insular lobe(OR=19.528,95%CI:1.354-281.677,P<0.05),and a TOAST classification of arteriolar occlusion(OR=7.877,95%CI:1.526-40.656,P<0.05)were risk factors for slowing of IPS after ischemic stroke in young and middle-aged patients.Conclusions There is a relatively high incidence rate of slowing of IPS after ischemic stroke in young and middle-aged patients,and patients with a relatively high NIHSS score before treatment,the infarction site of the temporal lobe,the insular lobe or the lateral ventricle,and the TOAST classification of arteri

关 键 词：缺血性脑卒中 信息处理速度 危险因素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]