Meningeal carcinomatosis in a patient with lung adenocarcinoma consulting an ophthalmologist first:a case report and literature review  

作　　者：Helei Wang Ying Li Chao Huang Shanshan Li Jianqiao Li 王合雷;李颖;黄超;李姗姗;李建桥(Department of Ophthalmology,Qilu Hospital of Shandong University,Jinan 250012,China;School of Instrumentation and Optoelectronic Engineering,Beihang University,Beijing 100191,China;Department of Geriatric Medicine,Qilu Hospital of Shandong University,Jinan 250012,China;Institute of Large-scale Scientific Facility and Centre for Zero Magnetic Field Science,Beihang University,Hangzhou 310051,China;National Institute of Extremely-Weak Magnetic Field Infrastructure,Hangzhou 310028,China;Key Laboratory of Cardiovascular Proteomics of Shandong Province,Qilu Hospital of Shandong University,Jinan 250012,China)

机构地区：[1]Department of Ophthalmology,Qilu Hospital of Shandong University,Jinan 250012,China [2]School of Instrumentation and Optoelectronic Engineering,Beihang University,Beijing 100191,China [3]Department of Geriatric Medicine,Qilu Hospital of Shandong University,Jinan 250012,China [4]Institute of Large-scale Scientific Facility and Centre for Zero Magnetic Field Science,Beihang University,Hangzhou 310051,China [5]National Institute of Extremely-Weak Magnetic Field Infrastructure,Hangzhou 310028,China [6]Key Laboratory of Cardiovascular Proteomics of Shandong Province,Qilu Hospital of Shandong University,Jinan 250012,China

出　　处：《Eye Science》2024年第4期290-298,共9页眼科学报(英文版)

摘　　要：Background:Meningeal carcinomatosis(MC)is a rare and serious complication associated with advanced hematologic and solid tumors.It can present with various ocular manifestations,and diagnosis is typically confirmed through magnetic resonance imaging and cerebrospinal fluid(CSF)analysis.Treatment often involves a combination of surgery,chemotherapy,and/or radiation;however,the disease is incurable,with a very low survival rate.Case presentation:A 46-year-old woman presented to the ophthalmology department with complaints of vision loss.Funduscopy revealed a severely swollen optic disc(Frisen grade 5)with no visible optic disc margin and splinter hemorrhages.A contrast-enhanced chest computed tomography scan showed pulmonary nodules in the apex of the left lung.Analysis of CSF obtained through lumbar puncture confirmed the presence of malignant cells compatible with a diagnosis of MC.Conclusions:MC is a severe complication of systemic cancer with a poor prognosis.Given that ocular symptoms can occasionally be the initial presentation,MC should be considered in patients experiencing vision loss or diplopia,even in the absence of an intraocular cause,neurologic symptoms,or a known history of systemic cancer.Comprehensive systemic examinations of major organs are crucial for early detection,diagnosis,and management of MC.

关 键 词：cerebrospinal fluid magnetic resonance imaging meningeal carcinomatosis vision loss 

分 类 号：R73[医药卫生—肿瘤]