4种生物活性支架对急性牙髓炎患者年轻恒牙再生牙髓活力的影响  

Effects of Four Bioactive Scaffolds on Pulp Regeneration Activity of Young Permanent Teeth in Patients with Acute Pulpitis

作　　者：任镱琳 岳亚瑞 高宁 REN Yilin;YUE Yarui;GAO Ning(Department of Dentistry and Endodontics,Affiliated Stomatological Hospital of Pingdingshan University,Pingdingshan 467000,China)

机构地区：[1]平顶山学院附属口腔医院牙体牙髓科,河南平顶山467000

出　　处：《河南医学研究》2025年第1期123-127,共5页Henan Medical Research

摘　　要：目的探究4种生物活性支架对急性牙髓炎患者年轻恒牙再生牙髓活力的影响。方法选择2018年3月至2022年2月于平顶山学院附属口腔医院就诊的172例(患牙184颗)急性牙髓炎患者,其中龋齿组84颗牙,外伤组100颗牙。两组均采用三氧化矿物凝聚体(MTA)、生物陶瓷材料(iRoot BP Plus)、脱细胞真皮基质(ADM)+MTA、富血小板纤维蛋白(PRF)+MTA这4种生物活性支架治疗,比较4种支架的临床疗效、根尖根管改善情况及治疗后患牙恢复情况。结果术后,龋齿组及外伤组患者中4种生物活性支架治疗后的临床疗效比较,差异有统计学意义(P<0.05),其中PRF+MTA组的临床疗效均高于MTA组、iRoot BP Plus组,差异有统计学意义(P<0.05);术后,4种生物活性支架治疗后龋齿组及外伤组患者的根管长度及根管壁厚度均增加;龋齿组及外伤组中,4组术后根管长度及根管壁厚度比较,差异有统计学意义(P<0.05),PRF+MTA组术后改善效果最好;术后,龋齿组及外伤组患者采用4种生物活性支架治疗后患牙恢复情况比较,差异无统计学意义(P>0.05)。结论4种不同种生物活性支架在急性牙髓炎患者的治疗中疗效不一,其中PRF+MTA组能更好地保存牙髓活力,促进患者早期恢复。Objective To explore the effects of four bioactive scaffolds on pulp regeneration activity of young permanent teeth in patients with acute pulpitis.Methods A total of 172 patients(184 offending teeth)with acute pulpitis treated in Affiliated Stomatological Hospital of Pingdingshan University were enrolled from March 2018 to February 2022,including 84 teeth in caries group and 100 teeth in trauma group.Both groups were treated with the four bioactive scaffolds[mineral trioxide aggregate(MTA),Bioceramic material(iRoot BP Plus),acellular dermal matrix(ADM)+MTA,platelet rich fibrin(PRF)+MTA].The clinical curative effect,improvement of apical root canal and recovery of offending teeth after treatment by the four scaffolds were compared.Results After surgery,the differences in clinical curative effect between the two groups were statistically significant(P<0.05).The clinical curative effect in PRF+MTA group was better than that in MTA group and iRoot BP Plus group(P<0.05).After surgery,root canal length and thickness of root canal wall were increased in both groups,and there were significant differences in root canal length and thickness of root canal wall by the four bioactive scaffolds in both groups(P<0.05).The postoperative improvement effect was the best in PRF+MTA group.After surgery,there was no significant difference in recovery of offending teeth between the two groups(P>0.05).Conclusion The four bioactive scaffolds have different curative effect in patients with acute pulpitis.Among them,PRF+MTA can better preserve pulp activity and promote early recovery of patients.

关 键 词：急性牙髓炎 三氧化矿物聚合物 生物陶瓷材料 脱细胞真皮基质 脱细胞真皮基质 恒牙 恒牙活力 

分 类 号：R781.3[医药卫生—口腔医学]