β-羟基-β-甲基丁酸改善神经系统危重症病人肌肉质量和神经功能的研究进展  

Progress of beta-hydroxy-beta-methylbutyrate in improving muscle mass and neurological function in neurocritically ill patients

作　　者：刘杰[1,2] 林宁 LIU Jie;LIN Ning(College of Medicine,Southwest Jiaotong University,Chengdu 610031,Sichuan,China;The Affiliated Hospital of Southwest Jiaotong Unversity/Western Theater General Hospital of the Chinese people's Liberation Armyu,Chengdu 610083,Sichuan,China)

机构地区：[1]西南交通大学医学院,四川成都610031 [2]西南交通大学附属医院/西部战区总医院营养科,四川成都610083

出　　处：《肠外与肠内营养》2024年第6期376-380,共5页Parenteral & Enteral Nutrition

基　　金：西部战区总医院院级联合攻关项目(KY2019006);四川省干部保健科研项目(川干研2021-1303);四川省自然科学基金(2022NSFSC1422)。

摘　　要：神经系统危重症病人出现肌肉质量减少、力量下降和神经功能损害是很常见的,肌肉萎缩和肌无力都会导致身体功能的损害,导致脱机时间延长、轻瘫或四肢瘫等临床特征,严重影响病人预后和生活质量。β-羟基-β-甲基丁酸盐(HMB)是人体必需的支链氨基酸亮氨酸的活性代谢产物,能促进蛋白质合成并减少其分解,作为一种外源性营养补充剂,近年来因其对肌肉代谢的改善作用而受到关注。本综述探讨了ICU内的神经系统重症病人不同阶段单独使用或联合使用HMB的营养补充剂对肌肉质量和神经功能的作用,为缓解神经系统危重症病人肌肉萎缩、改善神经功能提供新的治疗思路。Muscle mass loss,strength loss and neurological impairment are common in patients with neurological critical illnesses.Muscle atrophy and muscle weakness can lead to impairment of body functions,resulting in clinical features such as prolonged deconditioning time,light paralysis or quadriplegia,which seriously affects the prognosis and quality of life of patients.Beta-Hydroxy-beta-methylbutyrate(HMB)is an active metabolite of the essential branched-chain amino acid leucine,which promotes protein synthesis and reduces its catabolism.As an exogenous nutritional supplement,HMB has attracted attention in recent years because of its improvement of muscle metabolism.In this review,we investigated the effects of nutritional supplements with HMB alone or in combination at different stages on muscle mass and neurological function in neurocritically ill patients in ICUs to provide new therapeutic ideas for alleviating muscle atrophy and improving neurological function in neurocritically ill patients.

关 键 词：β-羟基-β-甲基丁酸盐 神经危重症 肌肉质量 神经功能 

分 类 号：R739.4[医药卫生—肿瘤] R459.3[医药卫生—临床医学]