碳点在口腔颌面部恶性肿瘤的诊断及治疗中的应用  

Application of carbon dots to the diagnosis and treatment of oral and maxillofacial malignant tumors

作　　者：符天宇 张雪 王思琪 郭程祎 董晓宇 程亚鹏 李锐[3] Fu Tianyu;Zhang Xue;Wang Siqi;Guo Chengyi;Dong Xiaoyu;Cheng Yapeng;Li Rui(School of Stomatology,Zhengzhou University,Zhengzhou 450052,China;Dept.of Oral Medicine,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Dept.of Oral and Maxillofacial Surgery,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学口腔医学院,郑州450052 [2]郑州大学第一附属医院口腔内科,郑州450052 [3]郑州大学第一附属医院口腔颌面外科,郑州450052

出　　处：《国际口腔医学杂志》2025年第1期25-33,共9页International Journal of Stomatology

摘　　要：近年来,随着纳米材料的发展和新型诊疗模式的进步,纳米医疗得到了研究者的广泛关注。碳点是一种具备荧光性能的零维纳米材料,可用于口腔癌诊疗,在提高检测灵敏度、减少药物不良反应及增强疗效上有明朗的前景,为口腔癌的诊疗提供了新的切入点。本文对基于碳点的口腔癌诊疗策略的研究进展进行综述,包括碳点在口腔癌的诊断、化学治疗、光动力治疗、光热治疗以及免疫治疗中的研究和应用,探讨碳点在口腔癌诊疗中的可行性,并对其在生物医学领域的进一步发展作出展望。Owing to advancements in nanomaterials and diagnostic and therapeutic modalities,nanomedicine has at‐tracted considerable interest.Carbon dots are zero-dimensional nanomaterials with fluorescent properties and applicable to the diagnosis and treatment of oral cancer.They potentially enhance detection sensitivity,reduce adverse drug reac‐tions,and improve therapeutic efficacy,thereby providing a new avenue for the management of oral cancer.This paper re‐views progress in research on carbon-dot-based strategies for oral cancer diagnosis and treatment and their applications in chemotherapy,photodynamic therapy,photothermal therapy,and immunotherapy.It also explores the feasibility of using carbon dots in oral cancer management and potential development in the biomedical field.

关 键 词：碳点 口腔癌 诊断 化学治疗 光动力治疗 光热治疗 免疫治疗 

分 类 号：R739.8[医药卫生—肿瘤]