Schlemm’s canal结构和功能调控的研究进展及其在青光眼治疗中的应用  

Research progress on the structure and functional regulation of Schlemm’s canal and its application in glaucoma treatment

作　　者：刘轲莉(综述) 张峰(审校) LIU Keli;ZHANG Feng(State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science,Guangzhou 510060,China)

机构地区：[1]中山大学中山眼科中心,眼病防治全国重点实验室,广东省眼科视觉科学重点实验室,广州510060

出　　处：《眼科学报》2024年第12期631-639,共9页Eye Science

基　　金：广东省自然科学基金面上项目,(2021A1515010553)。

摘　　要：Schlemm管(Schlemm’scanal,SC)作为房水流出的主要通道,通过调节房水外排来维持眼内压的平衡,其结构和功能的异常与高眼压及青光眼的发生发展密切相关。对SC的研究有助于阐明房水外排阻滞的发生机制、探索新的途径以增加房水排出,从而为降低眼压和青光眼治疗的新药物开发提供基础。目前,对SC发育和功能的调节机制的认识仍然有限,缺乏针对SC的特异性治疗策略。近年来,关于SC细胞命运决定及其结构发育的细胞学机制逐渐被揭示,功能调控的关键分子靶标也相继被发现,这促进了对SC结构和功能调控的深入理解。此外,作为降眼压药物靶点和针对性手术的创新应用也在不断拓展。文章系统回顾SC的结构与功能研究,总结关键的分子和细胞学调控机制,归纳SC靶向药物和手术疗法的最新进展,为青光眼的临床诊治提供了新的思路。Schlemm's canal(SC),as the primary pathway for aqueous humor drainage,maintains intraocular pressure balance by regulating aqueous outflow.Abnormalities in its structure and function are closely associated with elevated intraocular pressure and the development of glaucoma.Research on SC aids in elucidating the mechanisms behind outflow resistance and exploring new avenues to enhance aqueous drainage,thereby providing a foundation for the development of new drugs aimed at lowering intraocular pressure and treating glaucoma.Currently,our understanding of the mechanisms regulating SC development and functionality remains limited,with a lack of specific therapeutic strategies targeting SC.In recent years,advancements in measurement and imaging technologies have revealed the molecular and cellular mechanisms underlying SC development,leading to the identification of key regulatory targets.This has enhanced our understanding of SC structural and functional regulation.Furthermore,innovative applications of SC as a target for intraocular pressure-lowering medications and surgical interventions are continually expanding.This article systematically reviews the research on the structure and function of SC,summarizes the key molecular and cellular regulatory mechanisms,and discusses the latest advancements in SC-targeted pharmacological and surgical therapies,providing new insights for the clinical diagnosis and management of glaucoma.

关 键 词：SCHLEMM管 青光眼 房水流出平衡 眼压调节 

分 类 号：R775[医药卫生—眼科] R331.56[医药卫生—临床医学]