慢性肝病患者眼底表现及眼底检查的临床应用进展  

Ocular fundus manifestations and the clinical application of fundal examinations in patients with chronic liver disease:a systematic review

作　　者：曹子正 吴晓航 詹利强 吴雨璇 严安琪 黎松明(综述) 郭志勇[2] 林浩添(审校)[1] CAO Zizheng;WU Xiaohang;ZHAN Liqiang;WU Yuxian;YAN Anqi;LI Songming;GUO Zhiyong;LIN Haotian(State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science,Guangzhou 510060,China;The Organ Transplantation Center of the First Affiliated Hospital of Sun Yat-sen University,Key Laboratory of Organ Donation and Transplantation Immunology of Guangdong Province,International Science and Technology Cooperation Base for Organ Transplantation of Guangdong Province,Guangzhou 510080,China)

机构地区：[1]中山大学中山眼科中心,眼病防治全国重点实验室,广东省眼科视觉科学重点实验室,广州510060 [2]中山大学附属第一医院器官移植中心,广东省器官捐献与移植免疫学重点实验室,广东省器官移植国际科技合作基地,广州510080

出　　处：《眼科学报》2024年第12期640-647,共8页Eye Science

基　　金：国家自然科学基金重大研究计划重点支持项目(92368205),广州市卫生健康科技项目(2024A031004)。

摘　　要：慢性肝病(chronic liver disease,CLD)是一种或多种损伤因素长期作用于肝脏导致的疾病总称,其影响范围广、患者人群基数大。病毒性肝炎、非酒精性脂肪性肝病和终末期肝病等慢性肝病会累及眼底,造成视网膜渗出、出血等病变;同时眼底结构改变,如脉络膜和视网膜不同层次厚度,也与慢性肝病严重程度相关。对慢性肝病患者进行眼底检查不仅用于防治相关的眼底并发症,也对肝病临床评估及监测具有潜在应用价值。文章综述不同病因、严重程度和药物治疗下的慢性肝病患者可能出现的眼底病变,以及眼底结构功能检查在慢性肝病患者中的临床应用进展,以比较不同眼底检查方法在慢性肝病患者临床实施过程中的特点及适用场景,并提示未来在慢性肝病患者中应用眼底检查的潜在新方向。Chronic Liver Disease(CLD)is a collective term for diseases resulting from the long-term effects of one or more damaging factors on the liver.It has a broad impact and affects a large patient population.Viral hepatitis,non-alcoholic fatty liver disease,and end-stage liver disease can involve the ocular fundus,leading to retinal exudates and hemorrhages.Additionally,structural changes in the fundus,such as the thickness of the choroid and different retinal layers,are associated with the severity of chronic liver disease.Through fundus examinations in patients with chronic liver disease,not only can ocular complications related to liver disease be prevented and treated,but these examinations may also offer potential value in the clinical assessment and monitoring of liver disease.This article reviews the potential ocular fundus abnormalities in patients with chronic liver disease under different etiologies,severities,and drug treatments.It discusses the progress in the clinical application of fundus structure and function examinations in patients with chronic liver disease.It compares the characteristics and appropriate clinical scenarios of various fundus examination methods in these patients and suggests potential new directions for the future use of fundus examinations in chronic liver disease management.

关 键 词：慢性肝病 眼底检查 视网膜结构与血流 

分 类 号：R575.1[医药卫生—消化系统] R771.3[医药卫生—内科学]