脾氨肽联合重组人干扰素治疗宫颈人乳头瘤病毒感染及转阴率的效果  

The effect of spleen aminopeptide combined with recombinant human interferon in the treatment of cervical human papillomavirus infection and negative conversion rate

作　　者：陈朝红 钟晓芬 谭泉 CHEN Chaohong;ZHONG Xiaofen;TAN Quan(Department of Obstetrics and Gynecology,Second People's Hospital of Nankang District,Ganzhou City,Ganzhou,Jiangxi,341400,China)

机构地区：[1]赣州市南康区第二人民医院妇产科,江西赣州341400

出　　处：《当代医学》2024年第22期116-119,共4页Contemporary Medicine

基　　金：赣州市指导性科技计划项目(GZ2021ZSF473)。

摘　　要：目的探讨脾氨肽联合重组人干扰素治疗宫颈人乳头瘤病毒(human papilloma virus,HPV)感染患者的效果。方法选取2020年2月至2022年2月赣州市南康区第二人民医院收治的60例HPV患者作为研究对象,按照随机数字表法分为观察组与对照组,每组30例。对照组采用重组人干扰素治疗,观察组在对照组基础上采用脾氨肽治疗。比较两组临床疗效、HPV病毒载量及转阴率、炎症因子水平及不良反应发生率。结果观察组治疗总有效率为96.67%,高于对照组的73.33%,差异有统计学意义(P<0.05);治疗后,观察组HPV病毒载量低于对照组,HPV转阴率高于对照组,差异有统计学意义(P<0.05);治疗后,两组白细胞介素-10(interleukin-10,IL-10)水平均高于治疗前,肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、C反应蛋白(C-reactive protein,CRP)、白细胞介素-1β(interleukin-1β,IL-1β)水平均低于治疗前,且观察组IL-10水平高于对照组,TNF-α、CRP、IL-1β水平均低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为6.66%,低于对照组的26.67%,差异有统计学意义(P<0.05)。结论脾氨肽联合重组人干扰素治疗宫颈HPV感染效果明显,能降低HPV病毒载量,提高HPV转阴率,改善炎症因子水平,且降低并发症发生率,有利于疾病治疗。Objective To investigate the efficacy of spleen aminopeptide combined with recombinant human interferon in the treatment of cervical human papillomavirus(HPV)infection patients.Methods A total of 60 patients with HPV admitted to the Second People's Hospital of Nankang District of Ganzhou City from February 2020 to February 2022 were selected as the research subjects,they were divided into the observation group and the control group according to the random number table method,with 30 cases in each group.The control group was treated with recombinant human interferon,and the observation group was treated with spleen aminopeptide on the basis of the control group.The clinical efficacy,HPV viral load and negative conversion rate,inflammatory factor levels and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 96.67%,which was higher than 73.33%in the control group,and the difference was statistically significant(P<0.05);after treatment,the HPV viral load in the observation group was lower than that in the control group,and the HPV negative conversion rate was higher than that in the control group,the differences were statistically significant(P<0.05);after treatment,the levels of interleukin-10(IL-10)of the two groups were higher than those before treatment,and the levels of tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)and interleukin-1β(IL-1β)were lower than those before treatment,the level of IL-10 in the observation group was higher than that in the control group,and the levels of TNF-α,CRP and IL-1βwere lower than those in the control group,the differences were statistically significant(P<0.05);the incidence of adverse reactions in the observation group was 6.66%,which was lower than 26.67%in the control group,and the difference was statistically significant(P<0.05).Conclusion The spleen aminopeptide combined with recombinant human interferon is effective in treating cervical HPV infection,reducing HPV viral

关 键 词：脾氨肽 重组人干扰素 人乳头瘤病毒 转阴率 

分 类 号：R73[医药卫生—肿瘤]