儿童髓鞘少突胶质细胞糖蛋白抗体病及抗N-甲基-D-天门冬氨酸受体脑炎重叠综合征1例报道并文献复习  

Overlap syndrome of myelin oligodendrocyte glycoprotein-antibody disease and anti-N-methyl-Daspartatereceptor encephalities in children:a case report and literature review

作　　者：魏春苗 张琰 林彩梅 WEI Chunmiao;ZHANG Yan;LIN Caimei(Department of Neurology,Xiamen Children's Hostipal,Xiamen,Fujian,361000,China)

机构地区：[1]厦门市儿童医院神经内科,福建厦门361000

出　　处：《当代医学》2024年第22期120-123,共4页Contemporary Medicine

摘　　要：髓鞘少突胶质细胞糖蛋白(myelin oligodendrocyte glycoprotein,MOG)抗体病及抗N-甲基-D-天门冬氨酸受体(N-methyl-D-aspartate receptor,NMDAR)脑炎可在同一患儿体内先后或同时出现,这类疾病统称为MOG抗体病及抗NMDAR脑炎重叠综合征(MOG disease and anti-NMDAR-encephalitis overlap syndrome,MNOS),MNOS临床少见,临床症状易被临床医师忽视。本研究回顾性分析1例儿童MNOS病例的临床资料并总结相关文献,本研究患儿病初以抗NMDAR脑炎症状为主,癫痫发作常见,神经影像学无明显特异性;急性期一线治疗效果好,但易复发,及时识别并治疗后整体预后好。临床医师应早期识别儿童MNOS临床特点,及时行双抗体检测和对症治疗,以免延误病情,影响预后。Myelin oligodendrocyte glycoprotein-antibody disease(MOGAD)and anti-N-methyl-aspartatereceptor encephalities(NMDAR)appearing sequntially or simultaneously in the same patient.This kind of disease are collectively known as the overlapping syndrome of MOG-Ab disease and anti-NMDAR encephalities(MNOS),MNOS is a rare disease in clinical,clinical sympotoms are easily ignored by doctors.This study retrospectively analyzed a case of MNOS in children and summarized related literature,in this study,the symptoms of Anti-NMDAR encephalitis were predominant at the beginning of the disease,and seizures were common,there was no significant specificity in neuroimaging;first-line treatment in actue stage has good effect,but it is easy to relapse,and the overall prognosis is good after timely identification and treatment.Clinical octors should identify the clinical characteristics of MNOS in children early,conduct double-antibody detection in time,and treat them in time to avoid delaying the condition and affecting the prognosis.

关 键 词：抗N-甲基-D-天门冬氨酸受体脑炎 髓鞘少突胶质细胞糖蛋白抗体病合并抗N-甲基-D-天门冬氨酸受体脑炎重叠综合征 神经影像学 

分 类 号：R74[医药卫生—神经病学与精神病学]