中晚期宫颈癌腔内后装置放疗近期疗效的影响因素分析  

Analysis of the factors affecting short-term efficacy ofintracavitary brachytherapy in mid-late stage cervical cancer

作　　者：祝海峰 侯晓凤 梅珍霞 祝江红 余静 ZHU Haifeng;HOU Xiaofeng;MEI Zhenxia;ZHU Jianghong;YU Jing(Department of Gynecologic Oncology,Jiujiang Third People's Hospital,Jiujiang,Jiangxi,332000,China)

机构地区：[1]九江市第三人民医院妇瘤科,江西九江332000

出　　处：《当代医学》2024年第22期132-135,共4页Contemporary Medicine

基　　金：江西省卫生健康委普通科技计划(202211726)。

摘　　要：目的分析中晚期宫颈癌腔内后装置放疗近期疗效的影响因素。方法选取2019年1月至2021年1月九江市第三人民医院收治的60例中晚期宫颈癌腔内后装置放疗患者作为研究对象,收集患者治疗前CT影像学等临床资料,根据术后病理结果分为进展(progressive disease,PD)组、稳定(stable disease,SD)组、部分缓解(partial response,PR)组、完全缓解(complete remission,CR)组,各15例。单因素及多因素Logistic回归分析中晚期宫颈癌腔内后装置放疗患者近期疗效的影响因素。结果4组年龄、病理类型、体重指数比较差异无统计学意义;4组国际妇产科联盟(International Federation of Obstetrics and Gynecology,FIGO)分期、鳞状细胞抗原(squamous cell carcinoma antigen,SCCA)≥1.5μg/L占比比较差异有统计学意义(P<0.05)。CR组FIGO分期Ⅱ占比高于PD组、SD组及PR组,Ⅲ期占比低于PD组、SD组及PR组,SCCA≥1.5μg/L占比低于PD组与SD组,SD组与PR组均低于PD组,差异有统计学意义(P<0.05);其余组间两两比较差异无统计学意义。多因素Logistic回归分析显示,FIGO分期(Ⅲ期)、SCCA≥1.5μg/L是中晚期宫颈癌腔内后装置放疗近期疗效的影响因素(P<0.05)。结论FIGO分期、SCCA是中晚期宫颈癌患者腔内后装置放疗近期疗效的影响因素。Objective To analyze the factors affecting the short-term efficacy of intracavitary brachytherapy in mid-late stage cervical cancer.Methods 60 patients with mid-late stage cervical cancer treated with intracavitary brachytherapy at the Jiujiang Third People's Hospital from January 2019 to January 2021 were selected as the study subjects,clinical data including pre-treatment CT imaging were collected,and they were divided into the progression disease(PD)group,stable disease(SD)group,partial response(PR)group and the the complete remission(CR)group according to postoperative pathological results,with 15 cases in each group.Univariate and multivariate Logistic regression analysis of factors influencing short-term efficacy of intracavitary brachytherapy in mid-late stage cervical cancer.Results There were no statistically significant differences in age,pathological type and body mass index among the four groups;there were statistically significant differences in Federation of Obstetrics and Gynecology(FIGO)stage and squamous cell carcinoma antigen(SCCA)≥1.5μg/L among the four groups(P<0.05).The percentage of FIGO stageⅡin CR group was higher than that in the PD,SD and PR groups,the percentage of stageⅢwas lower than that in the PD,SD and PR groups,the percentage of SCCA≥1.5μg/L was lower than that in the PD and SD groups,and the SD and PR groups were lower than that in the PD group,and the differences were statistically significant(P<0.05);there was no statistically significant difference in two-by-two comparisons between the remaining groups.Multifactor Logistic regression analysis showed that FIGO stage(stageⅢ)and SCCA≥1.5μg/L were the influencing factors for the shortterm efficacy of intracavitary brachytherapy for mid-late stage cervical cancer(P<0.05).Conclusion FIGO stage and SCCA are factors influencing the short-term efficacy of intracavitary brachytherapy in patients with mid-late stage cervical cancer.

关 键 词：CT影像组学 中晚期 宫颈癌 后装置放疗 近期疗效 

分 类 号：R73[医药卫生—肿瘤]