内皮活化和应激指数与原发性胃肠道淋巴瘤患者临床特征及预后的关系  

Relationship between endothelial activation and stress index and clinical features and prognosis of patients with primary gastrointestinal lymphoma

作　　者：刘仪凡 赵娟 王丽娜[2] 席亚明[2] LIU Yifan;ZHAO Juan;WANG Lina;XI Yaming(The First Clinical Medical College of Lanzhou University,Gansu Lanzhou 730000,China;Department of Hematology,the First Hospital of Lanzhou University,Gansu Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,甘肃兰州730000 [2]兰州大学第一医院血液科,甘肃兰州730000

出　　处：《现代肿瘤医学》2025年第1期68-72,共5页Journal of Modern Oncology

摘　　要：目的:探索内皮活化和应激指数(endothelial activation and stress index,EASIX)与原发性胃肠道淋巴瘤(primary gastrointestinal lymphoma,PGIL)患者临床特征及预后的关系。方法:回顾性分析2000年01月01日至2022年12月30日兰州大学第一医院收治的74例初诊PGIL患者的临床资料,受试者工作特征(receiver operating characteristic,ROC)曲线确定EASIX的最佳截断值并分组;分类变量采用卡方检验或Fisher确切概率法比较,以频率和百分比表示,采用Kaplan-Meier生存曲线分析EASIX分组的PGIL患者的总生存期(OS),并用log-rank检验进行比较;采用Cox比例风险回归模型对OS进行单因素和多因素分析。结果:通过ROC曲线确定EASIX的最佳截断值为0.815。治疗前EASIX≤0.815的患者较多存在于Ann Arbor分期I-II期(P=0.005)、IPI评分为低危组及低中危组(P=0.006)的患者中,治疗前EASIX>0.815的患者较多存在于男性(P=0.047)、IPI评分为非低危组(P=0.006)的患者中。Kaplan-Meier生存曲线表明,高EASIX组比低EASIX组患者具有更差的OS。Cox多因素回归分析显示,具有A症状(HR=0.495,95%CI:0.260~0.941,P=0.032)、IPI评分高中危组、高危组(HR=3.384,95%CI:1.342~8.533,P=0.01)、EASIX>0.815(HR=2.607,95%CI:1.326~5.124,P=0.005)是影响PGIL患者OS的独立危险因素。结论:治疗前高EASIX是PGIL患者不良预后的危险因素,可用于临床上判断PGIL患者的预后。Objective:To explore the relationship between endothelial activation and stress index(EASIX)and clinical features and prognosis of patients with primary gastrointestinal lymphoma(PGIL).Methods:The clinical data of 74 patients with PGIL admitted to the First Hospital of Lanzhou University from January 1,2000 to December 30,2022 were retrospectively analyzed.Receiver operating characteristic(ROC)curve was used to determine the best cut-off value of EASIX.Categorical variables were compared using the chi-square test or Fisher's exact test and expressed as frequencies and percentages.The overall survival(OS)of PGIL patients with EASIX group was analyzed by Kaplan-Meier survival curve and compared by log-rank test.Cox proportional hazards regression model was used for univariate and multivariate analysis of OS.Results:The optimal cut-off value of EASIX was 0.815.Patients with EASIX≤0.815 before treatment were more in Ann Arbor stage I-II(P=0.005),low risk group and low intermediate risk group of IPI score(P=0.006).Before treatment,EASIX>0.815 was more common in male(P=0.047)and non-low risk IPI(P=0.006)patients.Kaplan-Meier survival curves indicated that patients in the high EASIX group had worse OS than those in the low EASIX group.Cox multivariate regression analysis showed that with A symptom(HR=0.495,95%CI:0.260~0.941,P=0.032),IPI score high-intermediate group and high risk group(HR=3.384,95%CI:1.342~8.533,P=0.01)and EASIX>0.815(HR=2.607,95%CI:1.326~5.124,P=0.005)were independent risk factors for OS in patients with PGIL.Conclusion:High EASIX before treatment is a risk factor for poor prognosis in patients with PGIL and can be used to evaluate the prognosis of patients with PGIL.

关 键 词：内皮活化和应激指数 原发性胃肠道淋巴瘤 临床特征 预后 

分 类 号：R733.4[医药卫生—肿瘤]