EGR1在前列腺癌组织中的表达及临床意义  

Expression and significance of EGR1 in prostate cancer tissues

作　　者：燕德伦 沈靖[2] 巩幼洁 马志厚 朱娅男 余娜 华浩铭 黄岩 王红群 YAN Delun;SHEN Jing;GONG Youjie;MA Zhihou;ZHU Yanan;YU Na;HUA Haoming;HUANG Yan;WANG Hongqun(Department of Surgery,the Third People's Hospital of Bengbu Affiliated to Bengbu Medical University,Anhui Bengbu 233099,China;Department of Pathology,the Third People's Hospital of Bengbu Affiliated to Bengbu Medical University,Anhui Bengbu 233099,China;Department of Pathology,the Second People's Hospital of Bengbu,Anhui Bengbu 233099,China;Department of Pathology,the Traditional Chinese Medicine Hospital of Bengbu City,Anhui Bengbu 233099,China)

机构地区：[1]蚌埠医科大学附属蚌埠市第三人民医院外科,安徽蚌埠233099 [2]蚌埠医科大学附属蚌埠市第三人民医院病理科,安徽蚌埠233099 [3]蚌埠市第二人民医院病理科,安徽蚌埠233099 [4]蚌埠市中医院病理科,安徽蚌埠233099

出　　处：《现代肿瘤医学》2025年第1期85-89,共5页Journal of Modern Oncology

基　　金：安徽省临床医学研究转化专项(编号:202204295107020051)。

摘　　要：目的:探讨早期生长应答因子1(early growth response gene 1,EGR1)在前列腺癌组织中的表达及意义。方法:使用免疫组化方法检测EGR1在前列腺癌组织中的表达情况,显微镜下观察,并统计分析。结果:EGR1在前列腺癌中的阳性率30.7%(23/75),其表达与AR呈负相关,也观察到在部分凋亡细胞中表达。EGR1在正常组织的表达低于前列腺癌组织(P<0.05),部分腺泡/导管的基底细胞阳性,在部分间质纤维细胞中阳性。结论:EGR1可能与前列腺癌的发生发展及凋亡相关。EGR1可能与基底细胞发育及纤维细胞的生长有关。Objective:To explore the expression and significance of early growth response gene 1(EGR1)in prostate cancer.Methods:The expression of EGR1 in prostate cancer tissues was detected using immunohistochemistry,observing under microscope,and statistically analysing.Results:The positive rate of EGR1 in prostate cancer were 30.7%(23/75),its expression was negatively correlated with AR,and was also observed in some apoptotic cells.The expression of EGR1 was lower than that of prostate cancer in normal tissues(P<0.05),and was positive in the basal cells of some follicles/ducts,and in some interstitial fibroblasts.Conclusion:EGR1 may be related to the development of prostate cancer tissues and may be associated with apoptosis.EGR1 may be related to the development of basal cells and associated with the growth of fibroblasts.

关 键 词：前列腺癌 EGR1 AR 基底细胞 分化 

分 类 号：R737.25[医药卫生—肿瘤]