探索CD164:从疾病标志物到治疗新策略  

Exploring CD164:From disease marker to new therapeutic strategies

作　　者：吴薇 魏金枫 徐辉[2] Abdulaziz 孙逊 陈天浩 邱洪斌[1] WU Wei;WEI Jinfeng;XU Hui;Abdulaziz;SUN Xun;CHEN Tianhao;QIU Hongbin(School of Public Health,Jiamusi University,Heilongjiang Jiamusi 154007,China;School of Basic Medical Sciences,Jiamusi University,Heilongjiang Jiamusi 154007,China)

机构地区：[1]佳木斯大学公共卫生学院,黑龙江佳木斯154007 [2]佳木斯大学基础医学院,黑龙江佳木斯154007

出　　处：《现代肿瘤医学》2025年第1期102-108,共7页Journal of Modern Oncology

基　　金：国家自然科学基金(编号:81273174);国家重点研发计划课题-精准医学研究(编号:2017YFC-0907404);黑龙江省自然科学基金重点项目(编号:ZD2022H006);黑龙江省省属高等学校基本科研业务费(编号:2022-KYYWF-0651);佳木斯大学省重点实验室开放课题(编号:TFYJ202301)。

摘　　要：近年来,有许多动物实验及临床研究表明CD164在多种疾病中表达异常,该文系统地综述了最新研究成果,发现CD164在不同疾病中均呈现出独特的表达模式,尤其在肿瘤、免疫系统疾病、人畜共患病及其他多种疾病中扮演着关键角色。深入分析这些研究发现,CD164不仅与各疾病的发生和发展密切相关,更可能成为未来疾病诊断与治疗的新靶点。进一步探讨CD164的功能和调控机制,将有望为疾病的早期诊断、精准治疗提供新的思路和方法,进而推动其在临床实践中的应用,为患者的健康带来更大的利益。In recent years,numerous animal experiments and clinical studies have demonstrated abnormal expression of CD164 in various diseases.This article systematically reviews the latest research findings and discovers that CD164 exhibits unique expression patterns in different diseases,particularly playing a critical role in tumors,immune system disorders,zoonotic diseases,and many other illnesses.An in-depth analysis of these studies reveals that CD164 is not only closely associated with the occurrence and development of various diseases but also has the potential to become a new target for future disease diagnosis and treatment.Further exploration of the function and regulatory mechanism of CD164 will hopefully provide new ideas and methods for early diagnosis and precise treatment of diseases,which will in turn promote its application in clinical practice and bring greater benefits to patients'health.

关 键 词：CD164 肿瘤 免疫系统疾病 人畜共患病 新靶点 

分 类 号：R730[医药卫生—肿瘤]