谷氨酰胺转运载体ASCT2在肿瘤中的研究进展  

Research progress of ASCT2 in cancer

作　　者：王春霞 张迪 赵丽霞[1] 杨熊飞[2,3] 张维胜 王涛[2,3] WANG Chunxia;ZHANG Di;ZHAO Lixia;YANG Xiongfei;ZHANG Weisheng;WANG Tao(The First Clinical Medical College of Gansu University of Chinese Medicine,Gansu Lanzhou 730000,China;Department of Anorectal,Gansu Provincial People's Hospital,Gansu Lanzhou 730000,China;Gansu Provincial Clinical Medical Research Center for Anorectal Diseases,Gansu Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学第一临床医学院,甘肃兰州730000 [2]甘肃省人民医院肛肠科,甘肃兰州730000 [3]甘肃省肛肠疾病临床医学研究中心,甘肃兰州730000

出　　处：《现代肿瘤医学》2025年第1期115-121,共7页Journal of Modern Oncology

基　　金：国家自然科学基金(编号:82160522);甘肃省自然科学基金项目(编号:22JR5RA653,22JR5RA676)。

摘　　要：谷氨酰胺代谢重编程是肿瘤发展进程中一种非常重要的生物学特征,是肿瘤快速生长的重要能量来源之一。某些肿瘤细胞在缺乏外源性谷氨酰胺时不能存活,表现出谷氨酰胺成瘾特性,其依靠异常活跃的谷氨酰胺转运系统来转运大量谷氨酰胺进入肿瘤细胞以维持其能量需求。丙氨酸-丝氨酸-半胱氨酸转运体2(alanine-serine-cysteine amino acid transporter-2,ASCT2)是高亲和力的谷氨酰胺转运载体,通过调控氨基酸代谢重编程参与了多种肿瘤的恶性进程,该文主要对ASCT2的结构、功能及其调控肿瘤的机制进行了综述。Glutamine metabolic reprogramming is a very important biological feature in the development of cancer,and is one of the important energy sources for the rapid growth of tumor.Some cancer cells cannot survive in the absence of exogenous glutamine,showing glutamine-addictive characteristics.They rely on the hyperactive glutamine transport system to transport large amounts of glutamine into tumor cells to maintain their energy requirements.alanine-serine-cysteine amino acid transporter-2(ASCT2)is a glutamine transporter with high affinity,which is involved in the malignant process of many tumors by regulating amino acid metabolism reprogramming.In this paper,the structure and function of ASCT2 and its mechanism of regulating cancer were reviewed.

关 键 词：丙氨酸-丝氨酸-半胱氨酸转运体2 谷氨酰胺 肿瘤 

分 类 号：R730[医药卫生—肿瘤]