线粒体靶向型抗癌肽的修饰及其抗肿瘤效果的研究进展  

Research progress of the modification and antitumor effect of anticancer peptides targeting mitochondria

作　　者：贾梓力 武荣荣 史惠[2] 刘磊 JIA Zili;WU Rongrong;SHI Hui;LIU Lei(Institute for Advanced Materials,School of Materials Science and Engineering,Jiangsu University,Jiangsu Zhenjiang 212013,China;School of Medicine,Jiangsu University,Jiangsu Zhenjiang 212013,China)

机构地区：[1]江苏大学材料科学与工程学院,新材料研究院,江苏镇江212013 [2]江苏大学医学院,江苏镇江212013

出　　处：《现代肿瘤医学》2025年第1期134-141,共8页Journal of Modern Oncology

基　　金：国家自然科学基金面上项目(编号:22072060)。

摘　　要：肿瘤精准诊疗是世界医学难题。寻找安全有效的癌症治疗药物及生物医学材料具有重要研究和转化价值。多肽类医用材料因其特异靶向性、低毒副作用性、良好可调控性等优点,在肿瘤治疗方面显示出巨大潜力,目前已有多种多肽被发现具有抗肿瘤特性并被运用于治疗中,其中以激活线粒体诱导细胞凋亡途径的抗癌肽(anticancer peptides,ACPs)研究最为广泛。但部分ACPs存在易被降解、细胞摄取量低等缺点。因此,如何改造ACPs并提升其治疗效率成为近年来生物医学领域的研究热点。该文着重于对常见的线粒体靶向型ACPs的多种修饰和改性方案进行回顾综述,并展望了线粒体靶向型ACPs的发展前景,期望未来对线粒体靶向型ACPs的改造研究提供新材料、新方案。Precise diagnosis and treatment of tumors poses a challenging issue in global medical field.There is significant research and transformation value to find safe and effective drugs and biomedical materials for cancer treatment.Peptide medical materials have emerged as a research hotspot in biomedical science in recent years,which have shown great tremendous potential in tumor treatment due to their specific targeting,weak side effects,outstanding controllability.Various peptides have been discovered to possess antitumor properties and have been utilized in treatment so far,among which research on anticancer peptides(ACPs)activating the mitochondrial-induced apoptotic pathway is most extensive.However,part of the ACPs exhibit drawbacks such as susceptibility to degradation and low efficiency for cell uptake.Therefore,the modification of the ACPs and improvement of the treatment efficiency have become a research hotspot in the biomedical field in recent years.In this paper,the modification strategies of the common ACPs targeting mitochondria were reviewed,and the future development of ACPs targeting mitochondria was prospected.It might provide new materials and solutions for the modification research of the ACPs targeting mitochondria in the future.

关 键 词：抗癌肽 癌细胞凋亡 线粒体 多肽修饰 生物医学应用 

分 类 号：R730.5[医药卫生—肿瘤]