肝癌合并门静脉癌栓的早期诊断  

Early diagnosis of portal vein tumor thrombus in hepatocellular carcinoma

作　　者：王欢 程树群 WANG Huan;CHENG Shuqun(The First Clinical Medical College of Guangdong Pharmaceutical University,Guangdong Guangzhou 510000,China;The Third Affiliated Hospital of Naval Medical University,Shanghai 200438,China)

机构地区：[1]广东药科大学第一临床医学院,广东广州510000 [2]海军军医大学第三附属医院,上海200438

出　　处：《现代肿瘤医学》2025年第1期142-148,共7页Journal of Modern Oncology

基　　金：国家重点研发计划项目(编号:2022YFC2503700);上海市重中之重-肝胆临床研究中心项目(编号:2023ZZ02005)。

摘　　要：肝细胞癌(hepatocellular carcinoma,HCC)是世界范围内最常见的原发性肝癌,也是慢性肝病患者常见的恶性肿瘤之一。在晚期诊断时,它通常与门静脉癌栓(portal vein tumor thrombus,PVTT)相关,这严重影响患者的预后。因此,早期检测PVTT对肝癌患者预后至关重要。PVTT预测模型是快速识别HCC伴PVTT高危人群的重要手段。彩色多普勒超声(CDUS)和超声造影(CEUS)是一种无创且易于重复的方法,能实时提供门静脉血流动态情况。计算机断层扫描(CT)和磁共振(MRI)是主要的诊断工具,在鉴别诊断良性血栓与恶性血栓中发挥重要作用。通过以上诊断方式以及利用生物学标志物的提示,实现HCC合并PVTT早期精准的诊断,从而达到早治疗的目的。Hepatocellular carcinoma(HCC)is the most common primary liver cancer worldwide and one of the most common malignancies in patients with chronic liver disease.When diagnosed at an advanced stage,it is usually associated with portal vein tumor thrombus(PVTT),which severely affects patient prognosis.Therefore,early detection of PVTT is crucial for the prognosis of patients with hepatocellular carcinoma.PVTT prediction model is an important tool for rapid identification of high-risk individuals with HCC combined with PVTT.Color Doppler ultrasound(CDUS)and ultrasonography(CEUS)are noninvasive and easily reproducible methods that provide real-time information on the dynamics of portal venous flow.Computed tomography(CT)and magnetic resonance imaging(MRI)are the main diagnostic tools that play an important role in the differential diagnosis of benign versus malignant thrombus.Through the above diagnostic modalities as well as the use of biological markers,the early and accurate diagnosis of HCC combined with PVTT can be realized and the goal of early treatment can be achieved.

关 键 词：肝细胞癌 门静脉癌栓 影像学诊断 生物标志物 早期诊断 

分 类 号：R730.4[医药卫生—肿瘤]