SLFN11参与DNA损伤应答作用机制的研究进展  

Research progress on the mechanism of SLFN11 involvement in DNA damage response

作　　者：何怡佳 杨柏轩 龙雨厚 娄鸣 苟兴春 张臻昊 高兴春 劳可静 HE Yijia;YANG Boxuan;LONG Yuhou;LOU Ming;GOU Xingchun;ZHANG Zhenhao;GAO Xingchun;LAO Kejing(School of Stomatology,Xi'an Medical University,Shaanxi Xi'an 710021,China;Shaanxi Key Laboratory of Brain Disorders&Institute of Basic and Translational Medical Science,Xi'an Medical University,Shaanxi Xi'an 710021,China;Department of lmmunology,School of Basic Medical Sciences,Xi'an Medical University,Shaanxi Xi'an 710021,China)

机构地区：[1]西安医学院口腔医学院,陕西西安710021 [2]陕西省脑疾病防治重点实验室,西安医学院基础与转化医学研究所,陕西西安710021 [3]西安医学院基础医学部免疫学教研室,陕西西安710021

出　　处：《现代肿瘤医学》2025年第1期149-157,共9页Journal of Modern Oncology

基　　金：陕西省自然科学基础研究计划项目(编号:2023-JC-QN-0137);陕西省青年科技新星项目(编号:2023KJXX-066);陕西省科技厅一般项目-社会发展领域(编号:2022SF-020);陕西省科技创新团队项目(编号:2021TD-48);陕西省教育厅青年创新团队项目(编号:23JP152);陕西省大学生创新创业训练计划项目(编号:S202211840053);西安医学院大学生创新训练计划项目(编号:121522053)。

摘　　要：肿瘤耐药已经成为化疗急需解决的问题。化疗药物的一类重要的分支是DNA损伤剂(DNA-damage agent,DDA),但肿瘤细胞可以通过DNA损伤应答(DNA-damage response,DDR)去修复损伤,从而降低了化疗药物的杀伤作用,因此阐明DNA损伤应答的机制,对于增加化疗药物的敏感性、减少化疗药物用量具有重要意义。Schlafen 11(SLFN11)是一种DNA/RNA解旋酶,可以增敏DNA损伤剂对肿瘤细胞的杀伤作用。已有的研究表明,SLFN11在多种肿瘤中的表达,其表达水平与肿瘤细胞DNA损伤剂的敏感性呈显著的正相关,因此SLFN11可成为潜在的肿瘤耐药生物标志物和药物靶点。本文就SLFN11的结构、参与DDR的作用机制及在不同肿瘤中应用的研究进展做一综述,为临床抗肿瘤精准治疗和创新药物开发提供新策略。Drug resistance has become an urgent problem to be solved in cancer chemotherapy.DNA-damage agents(DDA)are important drugs using in cancer chemotherapy,but cancer cells can repair the damage through DNA-damage response(DDR),thereby reducing the killing effect of chemotherapy drugs.Therefore,elucidating the mechanism of DNA-damage response is of great significance for increasing the sensitivity of chemotherapy drugs and reducing the dosage of chemotherapy drugs.Schlafen 11(SLFN11)is a DNA/RNA helicase that can sensitize the killing effect of DNA-damage agents on cancer cells.Previous studies have shown that the expression level of SLFN11 in various cancers is significantly positively correlated with the sensitivity of cancer cell DNA-damage agents.Therefore,SLFN11 can be used as a predictive biomarker and target of the therapeutic effect of chemotherapy drugs.This review summarises the structure of SLFN11,the mechanism of action involved in DDR,and the research progress in its application in different cancers,providing new strategies for precise anti-cancer therapy and innovative drug development in clinical treatment.

关 键 词：SLFN11 治疗靶点 耐药 DNA损伤应答 肿瘤 

分 类 号：R730[医药卫生—肿瘤]