基于GBD数据分析1990-2019年全球炎症性肠病的疾病负担变化趋势  

Analysis of the Global Burden of Inflammatory Bowel Disease from 1990 to 2019 Based on GBD Data

作　　者：张新茹 张星星[3] 陈志明 李曦 陈怡藤 王馨笛 郭瑜[1] 阮伟清[1] ZHANG Xinru;ZHANG Xingxing;CHEN Zhiming;LI Xi;CHEN Yiteng;WANG Xindi;GUO Yu;RUAN Weiqing(Huiqiao Medical Center,Southern Hospital,Southern Medical University,Guangzhou 510515,China;School of Nursing,Southern Medical University,Guangzhou 510515,China;Department of General Surgery,Southern Hospital,Southern Medical University,Guangzhou 510515,China;Department of Thoracic Surgery,Southern Hospital,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学南方医院惠侨医疗中心,510515 [2]南方医科大学护理学院,510515 [3]南方医科大学南方医院普通外科,510515 [4]南方医科大学南方医院胸外科,510515

出　　处：《现代消化及介入诊疗》2024年第10期1159-1163,共5页Modern Interventional Diagnosis and Treatment in Gastroenterology

基　　金：广东省科技计划项目(2022A1414020007)。

摘　　要：目的分析全球1990年至2019年炎症性肠病(inflammatory bowel disease,IBD)发病和死亡变化趋势,为制定全球炎症性肠病的预防与控制提供参考依据。方法数据来源自2019年全球疾病负担数据库(The Global Burden of Disease,GBD)。使用发病率、死亡率、残疾调整生命年(disability-adjusted life years,DALY)及年龄标准化率(age-standardized rates,ASRs)量化炎症性肠病全球疾病负担,通过估计的年百分比变化(estimated annual percentage changes,EAPC)评估ASRs的变化趋势。结果全球范围内,IBD的发病率、死亡率及DALY均呈现下降趋势,但地区差异较大。发病率的上升趋势出现在低SDI地区、中SDI地区、中低SDI地区,特别是东亚地区,死亡率的上升趋势只出现在高SDI地区,特别是大洋洲。90岁以上年龄组的发病人数(193.90%)、死亡人数(360.48%)和DALY(323.36%)百分比变化最大。结论IBD仍是一个丞待解决的巨大公共卫生问题,缩短诊断时间、优化药物剂量、重视老年患者的健康需求等防控策略可在一定程度上降低IBD全球疾病负担。Objective To analyze the trends in the global burden of inflammatory bowel disease(IBD)from 1990 to 2019.Methods Data were obtained from the 2019 Global Burden of Disease database(GBD).The global burden of IBD was quantified using incidence,mortality,disability-adjusted life years(DALY),and age-standardized rates(ASRs).The estimated annual percentage changes(EAPC)were used to assess the trends in ASRs.Results Globally,the incidence,mortality,and DALY of IBD showed a downward trend,but with significant variations.An increasing incidence trend was observed in low,middle,and lower-middle SDI regions,particularly in East Asia,while the increasing mortality trend was only observed in regions with higher SDI,especially in Oceania.The largest percentage changes in incidence(193.90%),mortality(360.48%),and DALY(323.36%)were found in the age group over 90 years.Conclusion IBD is still a huge public health problem to be solved.Prevention and control strategies such as reducing diagnosis time,optimizing drug dose,and paying attention to the health needs of elderly patients can reduce the global disease burden of IBD to a certain extent.

关 键 词：炎症性肠病 疾病负担 预测分析 发病 死亡 

分 类 号：R574[医药卫生—消化系统]