骨代谢标志物在恶性肿瘤骨转移中的研究进展  

Research Progress of Bone Metabolism Markers in Malignant Tumor Bone Metastasis

作　　者：蒋岚 牛瑶[1] 张镤月 桑国耀[1] JIANG Lan;NIU Yao;ZHANG Puyue;SANG Guoyao(Medical Laboratory Center,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China)

机构地区：[1]新疆医科大学第一附属医院医学检验中心,乌鲁木齐830054

出　　处：《医学综述》2025年第3期278-282,288,共6页Medical Recapitulate

基　　金：新疆医科大学第一附属医院横向课题(HX2024-17);新疆医科大学第一附属医院“青年科研起航”专项基金项目(2022YFY-QKQN-85)。

摘　　要：恶性肿瘤骨转移作为肿瘤难以治愈的并发症,严重影响患者的生活质量和生存率,常伴随高钙血症、病理性骨折及持续性骨痛等骨相关事件,早期诊断及干预对控制恶性肿瘤骨转移病情进展至关重要。骨代谢标志物(如骨碱性磷酸酶、骨钙素、骨保护素)作为骨骼代谢活动的敏感指标,在骨质疏松等代谢性骨病诊断中具有显著价值,且可能与肿瘤骨转移进程紧密相关。对骨代谢标志物在恶性肿瘤骨转移中的临床价值进行深入研究,有助于实现更精准的早期诊断。Malignant tumor bone metastasis,as an incurable complication of tumors,seriously affects the quality of life and survival rate of the patients,often accompanied by bone related events such as hypercalcemia,pathological fractures,and persistent bone pain.Early diagnosis and intervention are crucial for controlling the progression of malignant tumor bone metastasis.Bone metabolism markers(such as bone alkaline phosphatase,osteocalcin and osteoprotegerin),as sensitive indicators of bone metabolism activity,have significant value in the diagnosis of metabolic bone diseases such as osteoporosis,and may be closely related to the process of tumor bone metastasis.In-depth research on the clinical value of bone metabolism markers in malignant tumor bone metastasis can help achieve more accurate early diagnosis.

关 键 词：恶性肿瘤 骨转移 骨代谢标志物 

分 类 号：R730.4[医药卫生—肿瘤]