DCE-MRI定量灌注参数、血清趋化因子20水平与非小细胞肺癌患者临床病理特征的相关性及意义  

Correlation and significance of DCE-MRI quantitative perfusion parameters,serum C-C chemokine ligand-20 level with clinicopathological characteristics in patients with non-small cell lung cancer

作　　者：王培珍 余卫民 田成斌 WANG Peizhen;YU Weimin;TIAN Chengbin(Department of Radiology,General Hospital of Pingmei Shenma Group,Pingdingshan 467000,China)

机构地区：[1]平煤神马医疗集团总医院放射科,河南平顶山467000

出　　处：《黑龙江医药科学》2025年第1期5-8,共4页Heilongjiang Medicine and Pharmacy

基　　金：河南省医学科技攻关计划联合共建项目,编号:LHGJ20211132。

摘　　要：目的:探究动态增强磁共振成像(dynamic contrast-enhanced magnetic resonance imaging,DCE-MRI)定量灌注参数、血清趋化因子20(C-C chemokine ligand-20,CCL20)与非小细胞肺癌患者临床病理特征的相关性及意义。方法:收集2021年1月至2023年6月于平煤神马医疗集团总医院就诊的98例非小细胞肺癌患者作为研究组,另按照1:1原则选择同期98例肺部良性结节患者为对照组,比较两组DCE-MRI定量灌注参数、血清CCL20水平,进一步分析不同临床病理特征患者DCE-MRI定量灌注参数、血清CCL20水平,采用Spearman法及受试者工作特性(ROC)曲线分析上述参数与临床病理特征的相关性及联合诊断价值。结果:研究组入院时K^(trans)、K_(ep)、V_(e)及血清CCL20水平均高于对照组(P<0.05);不同临床病理特征患者DCE-MRI定量灌注参数、血清CCL20水平比较:Ⅲ期>Ⅰ-Ⅱ期、低分化>高、中分化(P<0.05)、淋巴结转移者>无淋巴结转移者(P<0.05);K^(trans)、K_(ep)、V_(e)及血清CCL20水平均与分化程度、临床分期、淋巴结转移呈正相关(P<0.05);K^(trans)、K_(ep)、V_(e)及血清CCL20水平单独及联合诊断非小细胞肺癌的AUC均>0.6,但各指标联合诊断的AUC最高,为0.852(P<0.05)。结论:DCE-MRI定量灌注参数、血清CCL20水平不仅与非小细胞肺癌患者临床病理特征存在密切相关性,其联合诊断可显著提高对非小细胞肺癌的诊断效能。Objective:To explore the correlation and significance of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)quantitative perfusion parameters,serum C-C chemokine ligand-20(CCL20)with clinicopathological characteristics in patients with non-small cell lung cancer.Methods:98 patients with non-small cell lung cancer in General Hospital of Pingmei Shenma Group from January 2021 to June 2023 were recruited as the study group,and 98 patients with benign pulmonary nodules in the same period were selected as the control group according to the principle of 1:1.The DCE-MRI quantitative perfusion parameters and serum CCL20 level were compared between the two groups,and the DCE-MRI quantitative perfusion parameters and serum CCL20 level were further analyzed among patients with different clinicopathological characteristics.Spearman's correlation analysis and receiver operating characteristic(ROC)curve analysis were used to evaluate the correlation between above parameters and clinicopathological characteristics,as well as their combined diagnostic value.Results:The levels of K^(trans),K_(ep),V_(e)and serum CCL20 in the study group were higher than those in the control group at admission(P<0.05).The comparison of DCE-MRI quantitative perfusion parameters and serum CCL20 levels among patients with different clinicopathological characteristics:stageⅢ>stageⅠ-Ⅱ,low differentiation>high and medium differentiation(P<0.05),lymph node metastasis>no lymph node metastasis(P<0.05);K^(trans),K_(ep),V_(e)and serum CCL20 levels were positively correlated with differentiation,clinical stage and lymph node metastasis(P<0.05).The AUC of K^(trans),K_(ep),V_(e)and serum CCL20 levels for the individual and combined diagnosis of NSCLC were all>0.6,but the AUC for the combined diagnosis was the highest,reaching 0.852(P<0.05).Conclusion:DCE-MRI quantitative perfusion parameters and serum CCL20 level are not only closely related to the clinicopathological characteristics of patients with non-small cell lung cancer,but also can signif

关 键 词：动态增强磁共振成像 非小细胞肺癌 趋化因子20 临床病理特征 相关性 

分 类 号：R731.2[医药卫生—肿瘤]