胃充盈超声造影联合血清miRNA-210对老年反流性食管炎的诊断价值  

Diagnostic value of gastric-filling contrast-enhanced ultrasonography combined with serum miRNA-210 in the diagnosis of reflux esophagitis in elderly people

作　　者：马世拓 汤丽健 戈林 巨丹丹 郑雪 郑绮华 吴冠萌 方军 MA Shi-tuo;TANG Li-jian;GE Lin(Department of Emergency Internal Medicine,Hebei Petro China Central Hospital,Langfang Hebei 065000,China;Department of Health and Geriatrics,Hebei Petro China Central Hospital,Langfang Hebei 065000,China;Department of Ultrasound Medicine,Hebei Petro China Central Hospital,Langfang Hebei 065000,China)

机构地区：[1]河北中石油中心医院急诊内科,河北廊坊065000 [2]河北中石油中心医院保健与老年医学科,河北廊坊065000 [3]河北中石油中心医院超声医学科,河北廊坊065000

出　　处：《临床和实验医学杂志》2024年第24期2604-2608,共5页Journal of Clinical and Experimental Medicine

基　　金：廊坊市科学技术研究与发展计划自筹经费项目(编号:2023013171);河北省医学科学研究课题项目(编号:20201250)。

摘　　要：目的探讨胃充盈超声造影联合血清微小RNA(miRNA)-210对老年反流性食管炎(RE)的诊断预测价值。方法回顾性纳入2023年10月至2024年3月于河北中石油中心医院就诊疑似胃食管反流病(GERD)老年患者140例作为研究对象。根据是否发生RE分为RE组(n=90)和非RE组(n=50)。进行胃充盈超声造影检查,记录超声造影声像图、超声解剖学结构特征如His角和腹段食管长度;采用实时荧光定量聚合酶链反应(PCR)法检测GERD患者血清miRNA-210表达水平。采用受试者操作特征(ROC)曲线分析血清His角、腹段食管长度、miRNA-210及联合对老年RE的诊断价值。结果RE组的His角为(67.77±7.11)°,大于非RE组[(53.95±5.12)°],腹段食管长度为(2.47±0.85)cm,小于非RE组[(3.56±0.78)cm],差异均有统计学意义(P<0.05)。RE组血清miRNA-210水平为5.17±1.55,明显高于非RE组(2.58±0.96),差异有统计学意义(P<0.05)。ROC曲线结果显示,胃充盈超声造影参数(His角、腹段食管长度)、血清miRNA-210及三者联合对患者RE发生的曲线下面积(AUC)为0.830、0.955、0.938、0.995;AUC比较结果显示,联合预测优于单独预测(P<0.05)。结论胃充盈超声造影检查、血清miRNA-210水平对老年RE具有较高的诊断价值,联合诊断价值最高。Objective To investigate the diagnostic predictive value of gastric-filling contrast-enhanced ultrasonography combined with serum microRNA(miRNA)-210 in the diagnosis of reflux esophagitis(RE)in the elderly population.Methods This study retrospectively included 140 elderly patients with suspected gastroesophageal reflux disease(GERD)who visited Hebei Petro China Central Hospital between October 2023 and March 2024 as study subjects.According to the occurrence of RE,they were divided into RE group(n=90)and non-RE group(n=50).Gastric-filling contrast-enhanced ultrasonography by the filling method was performed on all study subjects,and ultrasonographic sonograms,ultrasonic anatomical structural features such as His angle and length of the abdominal segmental esophagus were recorded.Real-time quantitative fluorescence-polymerase chain reaction(RT-qPCR)assay was detected using serum miRNA-210 expression levels in GERD patients.The diagnostic value of serum miRNA-210,His angle,abdominal segmental esophagus length and the combination for RE in the elderly was analyzed using the subject's work characteristics(ROC)curve.Results The His angle of the RE group was(67.77±7.11)°,which was greater than that of the non-RE group[(53.95±5.12)°],and the length of the abdominal esophagus was(2.47±0.85)cm,which was smaller than that of the non-RE group[(3.56±0.78)cm],the differences were statistically significant(P<0.05).The serum miRNA-210 level in the RE group was 5.17±1.55,which was significantly higher than that in the non-RE group(2.58±0.96),and the difference was statistically significant(P<0.05).The ROC curve analysis results showed that the area under the curve(AUC)of gastric filling ultrasonography parameters(His angle,abdominal segmental esophageal length),serum miRNA-210 and the combination of the three on the occurrence of RE in patients were 0.830,0.955,0.938,0.995;the results of AUC comparison showed that the combined prediction was superior to the individual prediction(P<0.05).Conclusion Gastric-filling contra

关 键 词：胃充盈超声造影 miRNA-210 老年人 反流性食管炎 诊断 

分 类 号：R73[医药卫生—肿瘤]