血尿酸水平与双相情感障碍的相关性分析  

Analysis of the Relationship between Blood Uric Acid Level and Bipolar Disorder

作　　者：白怡萱 BAI Yixuan(Department of Laboratory,Xiamen Xianyue Hospital(Xianyue Hospital Affiliated with Xiamen Medical College,Fujian Psychiatric Center,Fujian Clinical Research Center for Mental Disorders),Xiamen,Fujian 361000,China)

机构地区：[1]厦门市仙岳医院(厦门医学院附属仙岳医院,福建省精神医学中心,福建省精神疾病临床医学研究中心)检验科,福建厦门361000

出　　处：《中国医药指南》2025年第2期81-84,共4页Guide of China Medicine

摘　　要：目的探讨血尿酸水平与双相情感障碍(BD)的相关性。方法选取厦门市仙岳医院2023年1月—6月收治的324例住院BD患者纳入观察组,另外选取同期来院健康体检者282名纳入对照组。比较两组血尿酸水平,分析年龄、性别、发作状态对BD患者血尿酸水平的影响,分析血尿酸水平在双相情感障碍诊疗中的价值。结果观察组尿酸水平为(391.13±110.02)μmol/L,高于对照组的(347.29±88.66)μmol/L(P<0.05)。观察组男性BD患者尿酸高于正常参考值的比例为55.28%(89/161),高于女性BD患者的37.42%(61/163)(P<0.05)。观察组男性BD患者的尿酸值高于女性BD患者(P<0.05)。Pearson相关性分析显示,BD患者尿酸水平与年龄存在负相关关系(r=-0.115,P=0.039)。躁狂发作组、抑郁发作组、混合发作组和缓解状态组4个亚组间尿酸水平比较,差异无统计学意义(P>0.05)。结论血尿酸水平与双相情感障碍有较高相关性,可作为BD诊断的辅助指标,尤其有利于年轻患者早期鉴别诊断。BD患者高尿酸血症发病率高,临床需重视筛查尽早干预。监测血尿酸水平在区分双相情感障碍的发作状态中的价值不高。Objective To explore the correlation between serum uric acid levels and bipolar affective disorder(BD).Methods A total of 324 inpatients with BD admitted to Xiamen Xian’yue Hospital from January 2023 to June 2023 were included in the observation group,during the same period,282 healthy individuals came to the hospital for physical examinations and were included in the control group.The serum uric acid levels of the two groups were compared,and the impact of age,gender,and episode status on the serum uric acid levels of BD patients was analyzed.The value of serum uric acid levels in the diagnosis and treatment of bipolar affective disorder was also analyzed.Results The uric acid level in the observation group was(391.13±110.02)μmol/L,higher than that in the control group(347.29±88.66)μmol/L(P<0.05).The proportion of male BD patients in the observation group with uric acid above the normal reference value was 55.28%(89/161),higher than the 37.42%(61/163)of female BD patients(P<0.05).The uric acid levels of male BD patients in the observation group were higher than those of female BD patients(P<0.05).Pearson correlation analysis showed a negative correlation between the uric acid levels of BD patients and age(r=-0.115,P=0.039).There was no statistically significant difference in uric acid levels among the four subgroups of manic episode,depressive episode,mixed episode,and remission status(P>0.05).Conclusions Blood uric acid level has a high correlation with bipolar disorder and can be used as an auxiliary indicator for the diagnosis of BD.It is especially beneficial for the early differential diagnosis of young patients.The incidence of hyperuricemia in patients with BD is high.In clinical practice,attention should be paid to screening and early intervention as soon as possible.Monitoring blood uric acid level has little value in distinguishing the episode status of bipolar disorder.

关 键 词：双相情感障碍 尿酸 高尿酸血症 精神疾病 代谢疾病 

分 类 号：R749.4[医药卫生—神经病学与精神病学]